Inhibitory effect of ethanolamine plasmalogen on iron- and copper-dependent lipid peroxidation

Mohsen Zommara, Nobuhiko Tachibana, Kosuke Mitsui, Noriaki Nakatani, Masanobu Sakono, Ikuo Ikeda, Katsumi Imaizumi

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

The effect of ethanolamine plasmalogen (EtnPm) on lipid peroxidation was investigated in liposomal suspension of egg yolk phosphatidylcholine. EtnPm inhibited iron- and copper-dependent peroxidation in the presence of preformed hydroperoxides, although it was not effective for radical initiator mediated lipid peroxidation. EtnPm resulted in complete binding of iron to liposomal lipids, suggesting that EtnPm exerts its inhibitory effect on lipid peroxidation through inhibiting preformed peroxide decomposition by trapping transition metal ions.

Original languageEnglish
Pages (from-to)599-602
Number of pages4
JournalFree Radical Biology and Medicine
Volume18
Issue number3
DOIs
Publication statusPublished - 1995 Mar
Externally publishedYes

Keywords

  • Free radicals
  • Lipid peroxidation
  • Plasmalogen
  • Transition metals

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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