Inhibitory Effect of Cilazaprilat on Norepinephrine Release Induced by Renal Nerve Stimulation in Anesthetized Dogs

Susumu Satoh, Toshiyuki Matsuoka, Mizue Suzuki-Kusaba, Kiyoshi Chiba

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

In pentobarbital-anesthetized dogs, the increase in the renal norepinephrine secretion rate elicited by renal nerve stimulation (1 Hz) during infusion of angiotensin I (15 ng/kg/min) was partially but significantly inhibited (by 21–37%) after dosing with cilazaprilat (0.1 mg/kg), an angiotensin converting enzyme inhibitor, accompanied by a decrease in the renal venous plasma norepinephrine concentration. These results may suggest that cilazaprilat exerts at least a part of its hypotensive effect through decreasing the facilitatory action of endogenous angiotensin II on adrenergic transmission.

Original languageEnglish
Pages (from-to)287-289
Number of pages3
JournalThe Japanese Journal of Pharmacology
Volume48
Issue number2
DOIs
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Pharmacology

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