Inhibitory Effect of Cilazaprilat on Norepinephrine Release Induced by Renal Nerve Stimulation in Anesthetized Dogs

Susumu Satoh; Toshiyuki Matsuoka; Mizue Suzuki-Kusaba; Kiyoshi Chiba

doi:10.1254/jjp.48.287

Inhibitory Effect of Cilazaprilat on Norepinephrine Release Induced by Renal Nerve Stimulation in Anesthetized Dogs

Susumu Satoh, Toshiyuki Matsuoka, Mizue Suzuki-Kusaba, Kiyoshi Chiba

Clinical Research, Innovation and Education Center

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

In pentobarbital-anesthetized dogs, the increase in the renal norepinephrine secretion rate elicited by renal nerve stimulation (1 Hz) during infusion of angiotensin I (15 ng/kg/min) was partially but significantly inhibited (by 21–37%) after dosing with cilazaprilat (0.1 mg/kg), an angiotensin converting enzyme inhibitor, accompanied by a decrease in the renal venous plasma norepinephrine concentration. These results may suggest that cilazaprilat exerts at least a part of its hypotensive effect through decreasing the facilitatory action of endogenous angiotensin II on adrenergic transmission.

Original language	English
Pages (from-to)	287-289
Number of pages	3
Journal	The Japanese Journal of Pharmacology
Volume	48
Issue number	2
DOIs	https://doi.org/10.1254/jjp.48.287
Publication status	Published - 1988

ASJC Scopus subject areas

Pharmacology

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title = "Inhibitory Effect of Cilazaprilat on Norepinephrine Release Induced by Renal Nerve Stimulation in Anesthetized Dogs",

abstract = "In pentobarbital-anesthetized dogs, the increase in the renal norepinephrine secretion rate elicited by renal nerve stimulation (1 Hz) during infusion of angiotensin I (15 ng/kg/min) was partially but significantly inhibited (by 21–37%) after dosing with cilazaprilat (0.1 mg/kg), an angiotensin converting enzyme inhibitor, accompanied by a decrease in the renal venous plasma norepinephrine concentration. These results may suggest that cilazaprilat exerts at least a part of its hypotensive effect through decreasing the facilitatory action of endogenous angiotensin II on adrenergic transmission.",

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AU - Matsuoka, Toshiyuki

AU - Suzuki-Kusaba, Mizue

AU - Chiba, Kiyoshi

PY - 1988

Y1 - 1988

N2 - In pentobarbital-anesthetized dogs, the increase in the renal norepinephrine secretion rate elicited by renal nerve stimulation (1 Hz) during infusion of angiotensin I (15 ng/kg/min) was partially but significantly inhibited (by 21–37%) after dosing with cilazaprilat (0.1 mg/kg), an angiotensin converting enzyme inhibitor, accompanied by a decrease in the renal venous plasma norepinephrine concentration. These results may suggest that cilazaprilat exerts at least a part of its hypotensive effect through decreasing the facilitatory action of endogenous angiotensin II on adrenergic transmission.

AB - In pentobarbital-anesthetized dogs, the increase in the renal norepinephrine secretion rate elicited by renal nerve stimulation (1 Hz) during infusion of angiotensin I (15 ng/kg/min) was partially but significantly inhibited (by 21–37%) after dosing with cilazaprilat (0.1 mg/kg), an angiotensin converting enzyme inhibitor, accompanied by a decrease in the renal venous plasma norepinephrine concentration. These results may suggest that cilazaprilat exerts at least a part of its hypotensive effect through decreasing the facilitatory action of endogenous angiotensin II on adrenergic transmission.

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Inhibitory Effect of Cilazaprilat on Norepinephrine Release Induced by Renal Nerve Stimulation in Anesthetized Dogs

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