Abstract
In pentobarbital-anesthetized dogs, the increase in the renal norepinephrine secretion rate elicited by renal nerve stimulation (1 Hz) during infusion of angiotensin I (15 ng/kg/min) was partially but significantly inhibited (by 21–37%) after dosing with cilazaprilat (0.1 mg/kg), an angiotensin converting enzyme inhibitor, accompanied by a decrease in the renal venous plasma norepinephrine concentration. These results may suggest that cilazaprilat exerts at least a part of its hypotensive effect through decreasing the facilitatory action of endogenous angiotensin II on adrenergic transmission.
Original language | English |
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Pages (from-to) | 287-289 |
Number of pages | 3 |
Journal | The Japanese Journal of Pharmacology |
Volume | 48 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1988 |
ASJC Scopus subject areas
- Pharmacology