Abstract
The purpose of the study is to investigate the effect of ent-11a-hydroxy-15-oxo-kaur-16-en-19-oic-acid (5F) on the model of induced A/J mice lung cancer in A/J mice. The expressions of tumor-related molecules including P65 and Bcl-2 at protein level were examined using the immunohistochemical method (IHC). Side effects of 5F were also monitored. The results indicated that 5F significantly suppressed the development of B[a]P and NNK-induced lung cancer in vivo by facilitating cell apoptosis with minimal side effects. Compared to the expressions of P65 and Bcl-2 in model group, the levels were strongly attenuated both in blank and 5F injection groups. Moreover, P65 and Bcl-2 levels varied among different groups receiving 5F treatment. The expressions of P65 and Bcl-2 were much lower in groups receiving high-concentration 5F treatment than those with low-concentration 5F injection. Findings revealed that 5F inhibited the pathogenesis of lung cancer through accelerating apoptosis in a dose-dependent manner.
Original language | English |
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Pages (from-to) | 4138-4142 |
Number of pages | 5 |
Journal | International Journal of Clinical and Experimental Pathology |
Volume | 8 |
Issue number | 4 |
Publication status | Published - 2015 |
Keywords
- 5F
- A/J mice
- Induced lung cancer
- Suppression
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology