Inhibitory effect of 5F on development of lung cancer in A/J mice

Hua Ye, Xiaoqing Yang, Kefeng Wu, Li Li, Yingnian Lv, Yi Liu, Xuebao Zheng

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The purpose of the study is to investigate the effect of ent-11a-hydroxy-15-oxo-kaur-16-en-19-oic-acid (5F) on the model of induced A/J mice lung cancer in A/J mice. The expressions of tumor-related molecules including P65 and Bcl-2 at protein level were examined using the immunohistochemical method (IHC). Side effects of 5F were also monitored. The results indicated that 5F significantly suppressed the development of B[a]P and NNK-induced lung cancer in vivo by facilitating cell apoptosis with minimal side effects. Compared to the expressions of P65 and Bcl-2 in model group, the levels were strongly attenuated both in blank and 5F injection groups. Moreover, P65 and Bcl-2 levels varied among different groups receiving 5F treatment. The expressions of P65 and Bcl-2 were much lower in groups receiving high-concentration 5F treatment than those with low-concentration 5F injection. Findings revealed that 5F inhibited the pathogenesis of lung cancer through accelerating apoptosis in a dose-dependent manner.

Original languageEnglish
Pages (from-to)4138-4142
Number of pages5
JournalInternational Journal of Clinical and Experimental Pathology
Volume8
Issue number4
Publication statusPublished - 2015 Jan 1

Keywords

  • 5F
  • A/J mice
  • Induced lung cancer
  • Suppression

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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    Ye, H., Yang, X., Wu, K., Li, L., Lv, Y., Liu, Y., & Zheng, X. (2015). Inhibitory effect of 5F on development of lung cancer in A/J mice. International Journal of Clinical and Experimental Pathology, 8(4), 4138-4142.