Inhibitory action of lansoprazole and its analogs against Helicobacter pylori: Inhibition of growth is not related to inhibition of urease

K. Nagata, E. Takagi, M. Tsuda, T. Nakazawa, H. Satoh, M. Nakao, H. Okamura, T. Tamura

    Research output: Contribution to journalComment/debatepeer-review

    45 Citations (Scopus)

    Abstract

    The proton pump inhibitors omeprazole and lansoprazole and its acid- activated derivative AG-2000, which are potent and specific inhibitors of urease of Helicobacter pylori (K. Nagata, H. Satoh, T. Iwahi, T. Shimoyama, and T. Tamura, Antimicrob. Agents Chemother. 37:769-774,1993), inhibited the growth of H. pylori. The growth was inhibited not only in urease-positive clinical isolates but also in their urease-negative derivatives which had no urease polypeptides. AG-1789, a derivative of lansoprazole with no inhibitory activity against H. pylori urease, also inhibited the growth of both strains even more strongly than the urease inhibitors lansoprazole and AG-2000. Furthermore, the antibacterial activity of omeprazole and lansoprazole was not affected by glutathione or dithiothreitol, which completely abolished the inhibitory activity of lansoprazole against H. pylori urease. These results indicated that the inhibitory action of these compounds against the growth of H. pylori was independent from the inhibitory action against urease.

    Original languageEnglish
    Pages (from-to)567-570
    Number of pages4
    JournalAntimicrobial agents and chemotherapy
    Volume39
    Issue number2
    DOIs
    Publication statusPublished - 1995

    ASJC Scopus subject areas

    • Pharmacology
    • Pharmacology (medical)
    • Infectious Diseases

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