Inhibitory action of lansoprazole and its analogs against Helicobacter pylori: Inhibition of growth is not related to inhibition of urease

K. Nagata, E. Takagi, M. Tsuda, T. Nakazawa, H. Satoh, M. Nakao, H. Okamura, T. Tamura

Research output: Contribution to journalComment/debatepeer-review

45 Citations (Scopus)

Abstract

The proton pump inhibitors omeprazole and lansoprazole and its acid- activated derivative AG-2000, which are potent and specific inhibitors of urease of Helicobacter pylori (K. Nagata, H. Satoh, T. Iwahi, T. Shimoyama, and T. Tamura, Antimicrob. Agents Chemother. 37:769-774,1993), inhibited the growth of H. pylori. The growth was inhibited not only in urease-positive clinical isolates but also in their urease-negative derivatives which had no urease polypeptides. AG-1789, a derivative of lansoprazole with no inhibitory activity against H. pylori urease, also inhibited the growth of both strains even more strongly than the urease inhibitors lansoprazole and AG-2000. Furthermore, the antibacterial activity of omeprazole and lansoprazole was not affected by glutathione or dithiothreitol, which completely abolished the inhibitory activity of lansoprazole against H. pylori urease. These results indicated that the inhibitory action of these compounds against the growth of H. pylori was independent from the inhibitory action against urease.

Original languageEnglish
Pages (from-to)567-570
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume39
Issue number2
DOIs
Publication statusPublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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