Abstract
Effects of Ca2+ antagonists, verapamil and diltiazem, on uptake and release of Ca2+ by microsomes of the renal cortex were studied. Verapamil inhibited the ATP-dependent Ca2+ uptake by renal microsomes. Addition of 0.8 mM verapamil was required to produce 50% inhibition of the ATP-dependent Ca2+ uptake. Diltiazem also depressed the Ca2+ uptake of the microsomes. The inhibitory effect of both drugs on the Ca2+ uptake was not due to an increased permeability for Ca2+, since release of Ca2+ from the microsomes was not significantly affected by either drug. It is proposed that verapamil and diltiazem inhibit Ca2+ transport by interfering with an active process of Ca2+ accumulation in microsomes of the renal cortex.
Original language | English |
---|---|
Pages (from-to) | 913-917 |
Number of pages | 5 |
Journal | The Japanese Journal of Pharmacology |
Volume | 30 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1980 |
Externally published | Yes |
ASJC Scopus subject areas
- Pharmacology