Inhibitory action of calcium antagonists on atp-dependent calcium uptake by the renal cortical microsomes

Takashi Dan, Munekazu Gemba

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Effects of Ca2+ antagonists, verapamil and diltiazem, on uptake and release of Ca2+ by microsomes of the renal cortex were studied. Verapamil inhibited the ATP-dependent Ca2+ uptake by renal microsomes. Addition of 0.8 mM verapamil was required to produce 50% inhibition of the ATP-dependent Ca2+ uptake. Diltiazem also depressed the Ca2+ uptake of the microsomes. The inhibitory effect of both drugs on the Ca2+ uptake was not due to an increased permeability for Ca2+, since release of Ca2+ from the microsomes was not significantly affected by either drug. It is proposed that verapamil and diltiazem inhibit Ca2+ transport by interfering with an active process of Ca2+ accumulation in microsomes of the renal cortex.

Original languageEnglish
Pages (from-to)913-917
Number of pages5
JournalThe Japanese Journal of Pharmacology
Volume30
Issue number6
DOIs
Publication statusPublished - 1980 Jan 1

ASJC Scopus subject areas

  • Pharmacology

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