Inhibitors for expression of IgE receptor on human mast cell from Puerariae Flos

Satoru Tamura, Kunichika Yoshihira, Mariko Tokumaru, Xu Zisheng, Nobutoshi Murakami

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Bioassay-guided separation of the extract of the medicinal plant, Puerariae Flos, disclosed the two isoflavones tectorigenin (1) and genistein (2) as the inhibitors for expression of IgE receptor (FcRI), the key molecule triggering the allergic reactions, on human mast cells. As a result of analysis of structure-activity relationship of the naturally occurring and synthesized isoflavones, 7-O-methyl glycitein (11) was disclosed as the more potent inhibitor than tectorigenin (1). These isoflavone ingredients suppressed expression of FcRI more potently than the active flavonoids found previously. In addition, tectorigenin (1) was clarified to particularly reduce generation of γ-chain subunit to suppress expression of FcRI among the three subunits.

Original languageEnglish
Pages (from-to)3872-3875
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number13
DOIs
Publication statusPublished - 2010

Keywords

  • Anti-allergy
  • FcRI
  • Isoflavone
  • Pueraria thomsonii Benth
  • Puerariae Flos
  • Tectorigenin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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