TY - JOUR
T1 - Inhibitors for expression of IgE receptor on human mast cell from Puerariae Flos
AU - Tamura, Satoru
AU - Yoshihira, Kunichika
AU - Tokumaru, Mariko
AU - Zisheng, Xu
AU - Murakami, Nobutoshi
N1 - Funding Information:
We wish to thank Dr. Atsuo Kuramasu (Graduate School of Medicine, Tohoku University) for bestowing HMC-1 cell line. This work was supported in part by Research funds from San-Ei Gen F. F. I. Inc. The authors are grateful to the Chamber of Tea Association of Shizuoka Prefecture for financial support.
Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2010
Y1 - 2010
N2 - Bioassay-guided separation of the extract of the medicinal plant, Puerariae Flos, disclosed the two isoflavones tectorigenin (1) and genistein (2) as the inhibitors for expression of IgE receptor (FcRI), the key molecule triggering the allergic reactions, on human mast cells. As a result of analysis of structure-activity relationship of the naturally occurring and synthesized isoflavones, 7-O-methyl glycitein (11) was disclosed as the more potent inhibitor than tectorigenin (1). These isoflavone ingredients suppressed expression of FcRI more potently than the active flavonoids found previously. In addition, tectorigenin (1) was clarified to particularly reduce generation of γ-chain subunit to suppress expression of FcRI among the three subunits.
AB - Bioassay-guided separation of the extract of the medicinal plant, Puerariae Flos, disclosed the two isoflavones tectorigenin (1) and genistein (2) as the inhibitors for expression of IgE receptor (FcRI), the key molecule triggering the allergic reactions, on human mast cells. As a result of analysis of structure-activity relationship of the naturally occurring and synthesized isoflavones, 7-O-methyl glycitein (11) was disclosed as the more potent inhibitor than tectorigenin (1). These isoflavone ingredients suppressed expression of FcRI more potently than the active flavonoids found previously. In addition, tectorigenin (1) was clarified to particularly reduce generation of γ-chain subunit to suppress expression of FcRI among the three subunits.
KW - Anti-allergy
KW - FcRI
KW - Isoflavone
KW - Pueraria thomsonii Benth
KW - Puerariae Flos
KW - Tectorigenin
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U2 - 10.1016/j.bmcl.2010.05.038
DO - 10.1016/j.bmcl.2010.05.038
M3 - Article
C2 - 20627560
AN - SCOPUS:77954314999
VL - 20
SP - 3872
EP - 3875
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 13
ER -