Inhibition of the functional interplay between endoplasmic reticulum (ER) Oxidoreduclin-1α (Ero1α) and protein-disulfide isomerase (PDI) by the endocrine disruptor bisphenol A

Masaki Okumura; Hiroshi Kadokura; Shoko Hashimoto; Katsuhide Yutani; Shingo Kanemura; Takaaki Hikima; Yuji Hidaka; Len Ito; Kohei Shiba; Shoji Masui; Daiki Imai; Susumu Imaoka; Hiroshi Yamaguchi; Kenji Inaba

doi:10.1074/jbc.M114.564104

Inhibition of the functional interplay between endoplasmic reticulum (ER) Oxidoreduclin-1α (Ero1α) and protein-disulfide isomerase (PDI) by the endocrine disruptor bisphenol A

Masaki Okumura, Hiroshi Kadokura, Shoko Hashimoto, Katsuhide Yutani, Shingo Kanemura, Takaaki Hikima, Yuji Hidaka, Len Ito, Kohei Shiba, Shoji Masui, Daiki Imai, Susumu Imaoka, Hiroshi Yamaguchi, Kenji Inaba

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Background: Protein-disulfide isomerase (PDI) has previously been identified to bind bisphenol A (BPA), an endocrine disrupter.

Results: BPA inhibited Ero1α-PDI-mediated disulfide bond formation.

Conclusion: BPA significantly inhibited the Ero1α and PDI oxidative cycle, probably through closure of the substrate- and Ero1-binding pocket in the PDI bdomain. Significance: BPA may have inhibitory effects on oxidative folding of secretory and membrane proteins.

Original language	English
Pages (from-to)	27004-27018
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	289
Issue number	39
DOIs	https://doi.org/10.1074/jbc.M114.564104
Publication status	Published - 2014 Sep 26

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Okumura, M., Kadokura, H., Hashimoto, S., Yutani, K., Kanemura, S., Hikima, T., Hidaka, Y., Ito, L., Shiba, K., Masui, S., Imai, D., Imaoka, S., Yamaguchi, H., & Inaba, K. (2014). Inhibition of the functional interplay between endoplasmic reticulum (ER) Oxidoreduclin-1α (Ero1α) and protein-disulfide isomerase (PDI) by the endocrine disruptor bisphenol A. Journal of Biological Chemistry, 289(39), 27004-27018. https://doi.org/10.1074/jbc.M114.564104

Inhibition of the functional interplay between endoplasmic reticulum (ER) Oxidoreduclin-1α (Ero1α) and protein-disulfide isomerase (PDI) by the endocrine disruptor bisphenol A. / Okumura, Masaki ; Kadokura, Hiroshi; Hashimoto, Shoko et al.

In: Journal of Biological Chemistry, Vol. 289, No. 39, 26.09.2014, p. 27004-27018.

Research output: Contribution to journal › Article › peer-review

Okumura, M , Kadokura, H, Hashimoto, S, Yutani, K, Kanemura, S, Hikima, T, Hidaka, Y, Ito, L, Shiba, K, Masui, S, Imai, D, Imaoka, S, Yamaguchi, H & Inaba, K 2014, 'Inhibition of the functional interplay between endoplasmic reticulum (ER) Oxidoreduclin-1α (Ero1α) and protein-disulfide isomerase (PDI) by the endocrine disruptor bisphenol A', Journal of Biological Chemistry, vol. 289, no. 39, pp. 27004-27018. https://doi.org/10.1074/jbc.M114.564104

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title = "Inhibition of the functional interplay between endoplasmic reticulum (ER) Oxidoreduclin-1α (Ero1α) and protein-disulfide isomerase (PDI) by the endocrine disruptor bisphenol A",

abstract = "Background: Protein-disulfide isomerase (PDI) has previously been identified to bind bisphenol A (BPA), an endocrine disrupter.Results: BPA inhibited Ero1α-PDI-mediated disulfide bond formation.Conclusion: BPA significantly inhibited the Ero1α and PDI oxidative cycle, probably through closure of the substrate- and Ero1-binding pocket in the PDI bdomain. Significance: BPA may have inhibitory effects on oxidative folding of secretory and membrane proteins.",

author = "Masaki Okumura and Hiroshi Kadokura and Shoko Hashimoto and Katsuhide Yutani and Shingo Kanemura and Takaaki Hikima and Yuji Hidaka and Len Ito and Kohei Shiba and Shoji Masui and Daiki Imai and Susumu Imaoka and Hiroshi Yamaguchi and Kenji Inaba",

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doi = "10.1074/jbc.M114.564104",

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AU - Okumura, Masaki

AU - Kadokura, Hiroshi

AU - Hashimoto, Shoko

AU - Yutani, Katsuhide

AU - Kanemura, Shingo

AU - Hikima, Takaaki

AU - Hidaka, Yuji

AU - Ito, Len

AU - Shiba, Kohei

AU - Masui, Shoji

AU - Imai, Daiki

AU - Imaoka, Susumu

AU - Yamaguchi, Hiroshi

AU - Inaba, Kenji

PY - 2014/9/26

Y1 - 2014/9/26

N2 - Background: Protein-disulfide isomerase (PDI) has previously been identified to bind bisphenol A (BPA), an endocrine disrupter.Results: BPA inhibited Ero1α-PDI-mediated disulfide bond formation.Conclusion: BPA significantly inhibited the Ero1α and PDI oxidative cycle, probably through closure of the substrate- and Ero1-binding pocket in the PDI bdomain. Significance: BPA may have inhibitory effects on oxidative folding of secretory and membrane proteins.

AB - Background: Protein-disulfide isomerase (PDI) has previously been identified to bind bisphenol A (BPA), an endocrine disrupter.Results: BPA inhibited Ero1α-PDI-mediated disulfide bond formation.Conclusion: BPA significantly inhibited the Ero1α and PDI oxidative cycle, probably through closure of the substrate- and Ero1-binding pocket in the PDI bdomain. Significance: BPA may have inhibitory effects on oxidative folding of secretory and membrane proteins.

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Inhibition of the functional interplay between endoplasmic reticulum (ER) Oxidoreduclin-1α (Ero1α) and protein-disulfide isomerase (PDI) by the endocrine disruptor bisphenol A

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