Inhibition of the functional interplay between endoplasmic reticulum (ER) Oxidoreduclin-1α (Ero1α) and protein-disulfide isomerase (PDI) by the endocrine disruptor bisphenol A

Masaki Okumura; Hiroshi Kadokura; Shoko Hashimoto; Katsuhide Yutani; Shingo Kanemura; Takaaki Hikima; Yuji Hidaka; Len Ito; Kohei Shiba; Shoji Masui; Daiki Imai; Susumu Imaoka; Hiroshi Yamaguchi; Kenji Inaba

doi:10.1074/jbc.M114.564104

Inhibition of the functional interplay between endoplasmic reticulum (ER) Oxidoreduclin-1α (Ero1α) and protein-disulfide isomerase (PDI) by the endocrine disruptor bisphenol A

Masaki Okumura, Hiroshi Kadokura, Shoko Hashimoto, Katsuhide Yutani, Shingo Kanemura, Takaaki Hikima, Yuji Hidaka, Len Ito, Kohei Shiba, Shoji Masui, Daiki Imai, Susumu Imaoka, Hiroshi Yamaguchi, Kenji Inaba

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Background: Protein-disulfide isomerase (PDI) has previously been identified to bind bisphenol A (BPA), an endocrine disrupter.

Results: BPA inhibited Ero1α-PDI-mediated disulfide bond formation.

Conclusion: BPA significantly inhibited the Ero1α and PDI oxidative cycle, probably through closure of the substrate- and Ero1-binding pocket in the PDI bdomain. Significance: BPA may have inhibitory effects on oxidative folding of secretory and membrane proteins.

Original language	English
Pages (from-to)	27004-27018
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	289
Issue number	39
DOIs	https://doi.org/10.1074/jbc.M114.564104
Publication status	Published - 2014 Sep 26

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Okumura, M., Kadokura, H., Hashimoto, S., Yutani, K., Kanemura, S., Hikima, T., Hidaka, Y., Ito, L., Shiba, K., Masui, S., Imai, D., Imaoka, S., Yamaguchi, H., & Inaba, K. (2014). Inhibition of the functional interplay between endoplasmic reticulum (ER) Oxidoreduclin-1α (Ero1α) and protein-disulfide isomerase (PDI) by the endocrine disruptor bisphenol A. Journal of Biological Chemistry, 289(39), 27004-27018. https://doi.org/10.1074/jbc.M114.564104

Inhibition of the functional interplay between endoplasmic reticulum (ER) Oxidoreduclin-1α (Ero1α) and protein-disulfide isomerase (PDI) by the endocrine disruptor bisphenol A. / Okumura, Masaki ; Kadokura, Hiroshi; Hashimoto, Shoko; Yutani, Katsuhide; Kanemura, Shingo; Hikima, Takaaki; Hidaka, Yuji; Ito, Len; Shiba, Kohei; Masui, Shoji; Imai, Daiki; Imaoka, Susumu; Yamaguchi, Hiroshi; Inaba, Kenji.

In: Journal of Biological Chemistry, Vol. 289, No. 39, 26.09.2014, p. 27004-27018.

Research output: Contribution to journal › Article › peer-review

Okumura, M , Kadokura, H, Hashimoto, S, Yutani, K, Kanemura, S, Hikima, T, Hidaka, Y, Ito, L, Shiba, K, Masui, S, Imai, D, Imaoka, S, Yamaguchi, H & Inaba, K 2014, 'Inhibition of the functional interplay between endoplasmic reticulum (ER) Oxidoreduclin-1α (Ero1α) and protein-disulfide isomerase (PDI) by the endocrine disruptor bisphenol A', Journal of Biological Chemistry, vol. 289, no. 39, pp. 27004-27018. https://doi.org/10.1074/jbc.M114.564104

Okumura, Masaki ; Kadokura, Hiroshi ; Hashimoto, Shoko ; Yutani, Katsuhide ; Kanemura, Shingo ; Hikima, Takaaki ; Hidaka, Yuji ; Ito, Len ; Shiba, Kohei ; Masui, Shoji ; Imai, Daiki ; Imaoka, Susumu ; Yamaguchi, Hiroshi ; Inaba, Kenji. / Inhibition of the functional interplay between endoplasmic reticulum (ER) Oxidoreduclin-1α (Ero1α) and protein-disulfide isomerase (PDI) by the endocrine disruptor bisphenol A. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 39. pp. 27004-27018.

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abstract = "Background: Protein-disulfide isomerase (PDI) has previously been identified to bind bisphenol A (BPA), an endocrine disrupter.Results: BPA inhibited Ero1α-PDI-mediated disulfide bond formation.Conclusion: BPA significantly inhibited the Ero1α and PDI oxidative cycle, probably through closure of the substrate- and Ero1-binding pocket in the PDI bdomain. Significance: BPA may have inhibitory effects on oxidative folding of secretory and membrane proteins.",

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AU - Okumura, Masaki

AU - Kadokura, Hiroshi

AU - Hashimoto, Shoko

AU - Yutani, Katsuhide

AU - Kanemura, Shingo

AU - Hikima, Takaaki

AU - Hidaka, Yuji

AU - Ito, Len

AU - Shiba, Kohei

AU - Masui, Shoji

AU - Imai, Daiki

AU - Imaoka, Susumu

AU - Yamaguchi, Hiroshi

AU - Inaba, Kenji

PY - 2014/9/26

Y1 - 2014/9/26

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AB - Background: Protein-disulfide isomerase (PDI) has previously been identified to bind bisphenol A (BPA), an endocrine disrupter.Results: BPA inhibited Ero1α-PDI-mediated disulfide bond formation.Conclusion: BPA significantly inhibited the Ero1α and PDI oxidative cycle, probably through closure of the substrate- and Ero1-binding pocket in the PDI bdomain. Significance: BPA may have inhibitory effects on oxidative folding of secretory and membrane proteins.

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