Abstract
Background: Protein-disulfide isomerase (PDI) has previously been identified to bind bisphenol A (BPA), an endocrine disrupter.
Results: BPA inhibited Ero1α-PDI-mediated disulfide bond formation.
Conclusion: BPA significantly inhibited the Ero1α and PDI oxidative cycle, probably through closure of the substrate- and Ero1-binding pocket in the PDI bdomain. Significance: BPA may have inhibitory effects on oxidative folding of secretory and membrane proteins.
Original language | English |
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Pages (from-to) | 27004-27018 |
Number of pages | 15 |
Journal | Journal of Biological Chemistry |
Volume | 289 |
Issue number | 39 |
DOIs | |
Publication status | Published - 2014 Sep 26 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology