Inhibition of restriction enzymes EcoRI, BamHI and HindIII by phenethylphenylphthalimides derived from thalidomide

Kazunori Motoshima, Minoru Ishikawa, Yuichi Hashimoto, Kazuyuki Sugita

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We discovered inhibitors of the restriction enzymes EcoRI, BamHI and HindIII by screening our library of compounds with a phenethylphenylphthalimide skeleton, based on α-glucosidase inhibitors and liver X receptor antagonists derived from thalidomide. Structural development afforded the potent restriction enzyme inhibitors 25 and 26.

Original languageEnglish
Pages (from-to)880-884
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume59
Issue number7
DOIs
Publication statusPublished - 2011 Jul 1
Externally publishedYes

Keywords

  • Endonuclease
  • Enzyme inhibitor
  • Phthalimide
  • Restriction enzyme

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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