Inhibition of mucosal lipid hyperoxidation by green tea extract in 1,2-dimethylhydrazine-induced rat colonic carcinogenesis

Hirohiko Matsumoto, Tetsuro Yamane, Masao Inagake, Hirohisa Nakatani, Yasushi Iwata, Toshio Takahashi, Hiroshi Nishimura, Hoyoku Nishino, Kiyotaka Nakagawa, Teruo Miyazawa

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Phosphatidylcholine hydroperoxide (PCOOH) measured using a chemiluminescence detector to examine colonic mucosal lipid hyperoxidation increased after injection of 1,2-dimethylhydrazine and green tea extract (GTE), which we previously showed inhibited carcinogenesis and oxidative DNA damage in the gastrointestinal tract. Therefore, the hyperoxidation of membrane phospholipids reflected well the degree of DNA damage and carcinogenic alteration, and may be a useful intermediate biomarker for initiation of carcinogenesis.

Original languageEnglish
Pages (from-to)205-209
Number of pages5
JournalCancer Letters
Volume104
Issue number2
DOIs
Publication statusPublished - 1996 Jul 12

Keywords

  • 1,2-Dimethylhydrazine
  • Chemiluminescence
  • Green tea extract
  • Intermediate biomarker
  • Phosphatidylcholine hydroperoxide

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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