Inhibition of lymphatic metastasis in a syngeneic rat fibrosarcoma model by an angiogenesis inhibitor, AGM-1470

Hitoyasu Futami, Hideaki Iseki, Shin Ichi Egawa, Kotaro Koyama, Ken Yamaguchi

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

We examined whether lymphatic metastasis was inhibited by the potent angiogenesis inhibitor AGM-1470 [O-(chloroacetyl-carbamoyl)fumagillol, TNP-470] using a rat lymphatic metastasis model. Clone A of the rat fibrosarcoma AS653HM, when inoculated into the footpads of syngeneic rats, highly and preferentially metastasized to lymph nodes. In contrast, when AGM-1470 was administered subcutaneously to rats bearing the tumor cells, the tumor growth and incidence of metastasis in the lymph nodes were reduced in a dose- and schedule-dependent manner. Similar inhibition of lymphatic metastasis was also observed in the rats in which treatment with AGM-1470 was initiated following resection of the primary tumor in the foot, indicating that the treatment with AGM-1470 inhibited the progression of lymphatic metastasis at the metastatic sites of the lymph nodes. These results suggest that AGM-1470 can be a potential agent to prevent lymphatic metastasis.

Original languageEnglish
Pages (from-to)73-82
Number of pages10
JournalInvasion and Metastasis
Volume16
Issue number2
Publication statusPublished - 1996 Dec 1
Externally publishedYes

Keywords

  • AGM-1470
  • Angiogenesis
  • Angiogenesis inhibitor
  • Lymphatic metastasis
  • Rat fibrosarcoma

ASJC Scopus subject areas

  • Cancer Research

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