TY - JOUR
T1 - Inhibition of lymphatic metastasis in a syngeneic rat fibrosarcoma model by an angiogenesis inhibitor, AGM-1470
AU - Futami, Hitoyasu
AU - Iseki, Hideaki
AU - Egawa, Shin Ichi
AU - Koyama, Kotaro
AU - Yamaguchi, Ken
PY - 1996
Y1 - 1996
N2 - We examined whether lymphatic metastasis was inhibited by the potent angiogenesis inhibitor AGM-1470 [O-(chloroacetyl-carbamoyl)fumagillol, TNP-470] using a rat lymphatic metastasis model. Clone A of the rat fibrosarcoma AS653HM, when inoculated into the footpads of syngeneic rats, highly and preferentially metastasized to lymph nodes. In contrast, when AGM-1470 was administered subcutaneously to rats bearing the tumor cells, the tumor growth and incidence of metastasis in the lymph nodes were reduced in a dose- and schedule-dependent manner. Similar inhibition of lymphatic metastasis was also observed in the rats in which treatment with AGM-1470 was initiated following resection of the primary tumor in the foot, indicating that the treatment with AGM-1470 inhibited the progression of lymphatic metastasis at the metastatic sites of the lymph nodes. These results suggest that AGM-1470 can be a potential agent to prevent lymphatic metastasis.
AB - We examined whether lymphatic metastasis was inhibited by the potent angiogenesis inhibitor AGM-1470 [O-(chloroacetyl-carbamoyl)fumagillol, TNP-470] using a rat lymphatic metastasis model. Clone A of the rat fibrosarcoma AS653HM, when inoculated into the footpads of syngeneic rats, highly and preferentially metastasized to lymph nodes. In contrast, when AGM-1470 was administered subcutaneously to rats bearing the tumor cells, the tumor growth and incidence of metastasis in the lymph nodes were reduced in a dose- and schedule-dependent manner. Similar inhibition of lymphatic metastasis was also observed in the rats in which treatment with AGM-1470 was initiated following resection of the primary tumor in the foot, indicating that the treatment with AGM-1470 inhibited the progression of lymphatic metastasis at the metastatic sites of the lymph nodes. These results suggest that AGM-1470 can be a potential agent to prevent lymphatic metastasis.
KW - AGM-1470
KW - Angiogenesis
KW - Angiogenesis inhibitor
KW - Lymphatic metastasis
KW - Rat fibrosarcoma
UR - http://www.scopus.com/inward/record.url?scp=0030452904&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030452904&partnerID=8YFLogxK
M3 - Article
C2 - 9030242
AN - SCOPUS:0030452904
SN - 0251-1789
VL - 16
SP - 73
EP - 82
JO - Invasion and Metastasis
JF - Invasion and Metastasis
IS - 2
ER -
