Inhibition of ischemic brain edema formation by post-ischemic administration of a prostaglandin oligomer

S. Tsuyoshi Ohnishi, T. Tominaga, M. Katsuoka

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

We studied the efficacy of an oligomeric derivative of prostaglandin E1 in protecting the rat brain against focal ischemia. The degree of ischemic damage was evaluated from three parameters, namely, the degree of edema formation, reduction of motor performance, and memory disturbance as measured by a passive avoidance test. The pre-ischemic administration of the drug (6 mg/kg i.p.) had some effects, but the differences were not significant. The post-ischemic administration (6 mg/kg i.p.) produced significant improvement in all three parameters. The increase of water content of the ischemic hemisphere was reduced (p<0.05); the total motor score was improved (p<0.01); and the memory disturbance as estimated by the passive avoidance test was reduced (p<0.01). A possible mechanism of protection is discussed.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalProstaglandins, Leukotrienes and Essential Fatty Acids
Volume37
Issue number2
DOIs
Publication statusPublished - 1989 Aug
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

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