Inhibition Of Intravascular Mouse Melanoma Dissemination By Recombinant Human Interferon

Takahiko Yokoyama, Osamu Yoshie, Hisashi Aso, Takusaburo Ebina, Nakao Ishida

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of pure recombinant human interferonaA/D (IFNaA/D) on natural killer (NK) activity and the experimental lung metastasis of B16-F10 melanoma were studied. Treatment of C57BL/6 mice with IFNaA/D augmented splenic NK activity and also inhibited the experimental lung metastasis of B16-F10 melanoma in a dose-dependent manner. The augmentation of NK activity and the inhibition of experimental lung metastasis by IFNaA/D were completely abolished in anti-asialo GM1-pretreated mice. These results suggested that the effector cells which inhibited when it was given 12 hr before or at the same time as melanoma inoculation. This suggested that melanoma cells were susceptible to NK cells only for a short period of time after Hospital, 3-35-31 Taishido, Setagaya-ku, Tokyo 154 and *3Department of Pediatrics, Tokyo Medical and melanoma metastasis in the present system were mainly NK cells, and that it was by activating NK cells that IFNaA/D had its effect. We next studied the timing of IFNaA/D administration for the most effective prevention of melanoma metastasis. The inhibitory effect of IFNaA/D was most pronounced Dental College, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113intravascular invasion.

Original languageEnglish
Pages (from-to)135-138
Number of pages4
JournalThe Japanese Journal of Pharmacology
Volume49
Issue number1
Publication statusPublished - 1989 Jan 1

Keywords

  • Antitumor effect
  • B16 melanoma
  • Interferon
  • Metastasis
  • Natural killer cell

ASJC Scopus subject areas

  • Pharmacology

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