Inhibition of intravascular mouse melanoma dissemination by recombinant human interferonα A D

Takahiko Yokoyama, Osamu Yoshie, Hisashi Aso, Takusaburo Ebina, Nakao Ishida

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The effects of pure recombinant human interferonα A D (IFNα A D) on natural killer (NK) activity and the experimental lung metastasis of B16-F10 melanoma were studied. Treatment of C57BL 6 mice with IFNα A D augmented splenic NK activity and also inhibited the experimental lung metastasis of B16-F10 melanoma in a dose-dependent manner. The augmentation of NK activity and the inhibition of experimental lung metastasis by IFNα A D were completely abolished in anti-asialo GM1-pretreated mice. These results suggested that the effector cells which inhibited melanoma metastasis in the present system were mainly NK cells, and that it was by activating NK cells that IFNα A D had its effect. We next studied the timing of IFNα A D administration for the most effective prevention of melanoma metastasis. The inhibitory effect of IFNα A D was most pronounced when it was given 12 hr before or at the same time as melanoma inoculation. This suggested that melanoma cells were susceptible to NK cells only for a short period of time after intravascular invasion.

Original languageEnglish
Pages (from-to)80-84
Number of pages5
JournalJapanese Journal of Cancer Research
Volume77
Issue number1
Publication statusPublished - 1986 Jan 1

Keywords

  • Antitumor effect
  • B16 melanoma
  • Interferon
  • Metastasis
  • Natural killer cell

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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