Inhibition of F-box protein FBXO6 gene expression by RNA interference enhances cadmium toxicity in HEK293 cells

Gi Wook Hwang, Ke Du, Tsutomu Takahashi, Akira Naganuma

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Cadmium is a typical environmental pollutant and the causative agent of itai-itai disease. Ubiquitin ligases potentially involved in mediating the effects of cadmium toxicity were investigated by RNA interference using a panel of small inhibitory (si)RNAs. The results demonstrated that the inhibition of gene expression of FBXO6 sensitizes HEK293 cells to cadmium.

Original languageEnglish
Pages (from-to)847-849
Number of pages3
JournalJournal of Toxicological Sciences
Volume36
Issue number6
DOIs
Publication statusPublished - 2011 Dec 9

Keywords

  • Cadmium
  • F-box protein
  • FBXO6
  • Ubiquitin ligase

ASJC Scopus subject areas

  • Toxicology

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