Inhibition of cell growth and tumorigenesis of human glioblastoma cells by a neutralizing antibody against human basic fibroblast growth factor

Jun A. Takahashi, Manabu Fukumoto, Yoshio Kozai, Nobuyuki Ito, Yoshifumi Oda, Haruhiko Kikuchi, Masakazu Hatanaka

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

We report here that a neutralizing mouse monoclonal antibody against basic FGF inhibited both anchorage-dependent and anchorage-independent growth of U-87MG and T98G human glioblastoma cells and HeLa cells, all of which express both the basic FGF and the FGF remptor genes. In addition, the subcutaneous administration of this antibody significantly suppressed the tumor development or these tumor cells in nude mice. Therefore, basic FGF plays an important role in neoplastic growth of these cells. The neutralization or basic FGF will be effective in controlling the growth of tumors, such as glioblastoma and other cancer cells which bear basic FGF and FGF receptors.

Original languageEnglish
Pages (from-to)65-71
Number of pages7
JournalFEBS Letters
Volume288
Issue number1-2
DOIs
Publication statusPublished - 1991 Aug 19

Keywords

  • Basic fibroblast growth Factor
  • Fibroblast growth factor receptor
  • Glioblastoma
  • HeLa cell
  • Mouse monoclonal antibody

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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