Inhibition of bone resorption in cultures of mouse calvariae by apicularen A

Jang Ja Hong, Hirokazu Sasaki, Kazuaki Niikura, Maiko Yanai, Yasuhiro Nakano, Aya Yokomakura, Kenji Ishihara, Noriyasu Hirasawa, Young Sook Kang, Sub Oh Joa, Hwan Kwak Jong, Ok Pyo Zee, Kazuo Ohuchi

Research output: Contribution to journalArticlepeer-review

Abstract

Apicularens A and B were isolated from the myxobacterial genus Chondromyces apiculatus JW184. Apicularen A inhibited bafilomycin A1-sensitive ATP-dependent proton transport into microsome vesicles more potently than apicularen B. Bone resorption in cultures of mouse calvariae induced by human parathyroid hormone (PTH) or interleukin-1β (IL-1β) was inhibited by apicularen A at 10 and 100 nM, while apicularen B had no effect. The bisphosphonate incadronate inhibited bone resorption at 100 nM, being less effective than apicularen A. Our findings indicate that apicularen A inhibits bone resorption induced by PTH or IL-1β more potently than apicularen B, probably due to inhibition of the V-ATPase.

Original languageEnglish
Pages (from-to)173-175
Number of pages3
JournalPlanta Medica
Volume73
Issue number2
DOIs
Publication statusPublished - 2007 Feb 1

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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