Inhibition of 5-fluorouracil-cisplatin-induced stomatitis by oral cryotherapy: Use of an ice-bar containing fibrinolysin and deoxyribonuclease combined (Elase®)

A. Sato, S. Kumagai, K. Sakaki, H. Morikawa, S. T. Song, Shiro Mori

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Stomatitis caused by a combined chemotherapy with 5-fluorouracil (5-FU) and cisplatin (CDDP) is a serious problem in the course of treatment for patients with oral carcinoma. In the present study, we proposed a form of cryotherapy using an ice - bar containing fibrinolysin and deoxyribonuclease (Elase ®) to inhibit the stomatitis. The therapeutic effect of the ice-bar cryotherapy was evaluated in 20 patients with oral squamous cell carcinoma who were undergoing 5-FU-CDDP chemotherapy. Nine of the 20 patients were given the ice-bar cryotherapy while the remaining patients were not. As a result, although there was no significant difference between the incidence of stomatitis in the groups with and without the ice-bar cryotherapy, the incidence of severe stomatitis with ulcers and/or eating disturbance in the 11 cases without the ice-bar cryotherapy (90 %) was significantly higher than that in the 9 cases with the cryotherapy (44 %) (p<0.05). However, no significant difference in the clinical response rate of the 5-FU-CDDP chemotherapy was observed between the two groups.

Original languageEnglish
Pages (from-to)1135-1139
Number of pages5
JournalJapanese Journal of Cancer and Chemotherapy
Volume24
Issue number9
Publication statusPublished - 1997 Sep 25

Keywords

  • Cancer chemotherapy
  • Elase®-cryotherapy
  • Stomatitis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Inhibition of 5-fluorouracil-cisplatin-induced stomatitis by oral cryotherapy: Use of an ice-bar containing fibrinolysin and deoxyribonuclease combined (Elase®)'. Together they form a unique fingerprint.

Cite this