Abstract
Background: Although procaterol is used clinically as a β2-adrenergic receptor agonist to relax airway smooth muscle, it has not yet been clarified whether procaterol has inotropic effects on respiratory muscles. Methods: Three intervention groups were investigated: a procaterol inhalation only group; a procaterol inhalation plus endotoxin injection group (in vivo); and a procaterol incubation group (in vitro). The diaphragm muscle in all groups was dissected and measurements of its contractile properties were performed. Results: The effects of procaterol inhalation shifted the force-frequency curves upward at 30 minutes after inhalation, and inhibited the decline of force-frequency curves due to endotoxin injection in vivo. In vitro administration of procaterol resulted in an increase in the force-frequency curves in a dose-dependent manner. Conclusions: It can be concluded that procaterol has an inotropic effect on the diaphragmatic muscles taken from normal animals as well as on the diaphragm muscles in a septic animal model.
Original language | English |
---|---|
Pages (from-to) | 285-291 |
Number of pages | 7 |
Journal | Allergology International |
Volume | 56 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2007 Sep |
Keywords
- COPD
- Diaphragm muscle
- Endotoxin
- Respiratory muscle fatigue
- β2-agonists
ASJC Scopus subject areas
- Immunology and Allergy