Infusion of nicotine into the LHA enhances dopamine and 5-HT release and suppresses food intake

Zhong Jin Yang, Vladimir Blaha, Michael M. Meguid, Albert Oler, Go Miyata

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

Nicotine administration induces hypophagia. Because of the involvement of hypothalamic neurotransmitters in food intake control, we hypothesized that increased activity of the lateral hypothalamic dopamine (LHA-DA) and/or serotonin (LHA-5-HT) may be responsible for nicotine-induced hypophagia. Either 4 mM nicotine or vehicle was administered via reverse microdialysis technique into the LHA of overnight food-deprived rats for 60 min; then food was provided for 40 min. The LHA-DA, 5-HT and their intermediate metabolites, DOPAC and 5-HIAA, were continuously measured during 20-min intervals before, during, and after nicotine administration. Continuous nicotine administration for 60 min increased LHA-DA and DOPAC concentrations during the first 40 min, and induced a long-lasting increase in LHA-5-HT release, until 120 min after the start nicotine administration, even when nicotine administration was stopped. The food intake during the 40-min refeeding period was significantly lower when rats received nicotine. Eating induced a significant and short-lasting increase in the LHA-DA and a long-lasting increase in the LHA-5-HT. These findings indicate that nicotine enhances dopaminergic and serotonergic activity in the LHA, and that the enhanced LHA-5-HT activity may contribute to nicotine-induced hypophagia. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)155-159
Number of pages5
JournalPharmacology Biochemistry and Behavior
Volume64
Issue number1
DOIs
Publication statusPublished - 1999 Sep 1

Keywords

  • Dopamine
  • Food intake
  • Hypophagia
  • Lateral hypothalamic area
  • Microdialysis
  • Nicotine
  • Serotonin

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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