Infrequent genetic alterations of the PTEN/MMAC1 gene in Japanese patients with primary cancers of the breast, lung, pancreas, kidney, and ovary

Akira Sakurada, Akihiko Suzuki, Masami Sato, Hiromitsu Yamakawa, Kazuhiko Orikasa, Shinji Uyeno, Tetsuya Ono, Noriaki Ohuchi, Shigefumi Fujimura, Akira Horii

Research output: Contribution to journalArticlepeer-review

99 Citations (Scopus)

Abstract

In the present study, we searched for genetic alterations of the entire coding region of PTEN/MMAC1, a recently isolated candidate tumor suppressor gene, in 178 specimens from Japanese patients with various malignant tumors by the polymerase chain reaction-single strand conformation polymorphism method. The samples consisted of 11 glioblastoma multiformes (GBMs), 14 astrocytomas, 47 breast cancers, 25 non-small cell lung cancers, 9 small cell lung cancers, 8 pancreatic cancers, 24 renal cell carcinomas, 20 ovarian cancers, and 20 metastatic lung tumors from various organs. Only one somatic frameshift mutation at codon 319 was observed in one (9%) of eleven GBMs. Our results suggest that mutation of the PTEN/MMAC1 gene does not play a major role in carcinogenesis, at least in the tumor types from Japanese patients analyzed in this study.

Original languageEnglish
Pages (from-to)1025-1028
Number of pages4
JournalJapanese Journal of Cancer Research
Volume88
Issue number11
DOIs
Publication statusPublished - 1997 Nov

Keywords

  • Glioblastoma multiforme
  • PTEN/MMAC1 gene
  • Somatic mutation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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