Infrequent genetic alterations of the PTEN* gene in Japanese patients with sporadic prostate cancer

Kazuhiko Orikasa, Shin Ichi Fukushige, Senji Hoshi, Seiichi Orikasa, Keiichi Kondo, Yasuhide Miyoshi, Yoshinobu Kubota, Akira Horii

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Prostate cancer is a major cause of cancer death among elderly men in America, Europe, and Japan. However, the molecular mechanism of carcinogenesis is not yet well characterized. Frequent loss of heterozygosity (LOH) on chromosome 10q was reported in prostate cancer, and a candidate tumor suppressor gene, PTEN, was isolated on chromosome band 10q23.3. To investigate the genetic alterations of PTEN, we examined 45 primary prostate cancer specimens. LOH at the PTEN locus was observed in two (11.1%) of 18 tumors. However, no mutations were observed in any of the primary prostate cancers. These data suggest that mutation of the PTEN gene does not play a major role in prostate carcinogenesis of Japanese patients.

Original languageEnglish
Pages (from-to)228-230
Number of pages3
JournalJournal of Human Genetics
Volume43
Issue number4
DOIs
Publication statusPublished - 1998

Keywords

  • Chromosome 10q
  • Loss of heterozygosity (LOH)
  • PTEN gene
  • Prostate cancer
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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