Infratentorial brain metastases of pediatric non-epithelial malignant tumors: Three case reports

Shin Ichiro Osawa, Toshihiro Kumabe, Ryuta Saito, Yukihiko Sonoda, Hidetaka Niizuma, Mika Watanabe, Teiji Tominaga

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Three pediatric patients with infratentorial metastatic non-epithelial malignant brain tumors were successfully treated by radical surgical resection followed by aggressive radiochemotherapy. One patient with neuroblastoma and two with rhabdomyosarcoma were successfully treated by first line multimodal treatments, but developed infratentorial metastasis after several months of remission. All patients revealed intracranial metastases manifesting as rapidly progressing neurological symptoms caused by mass effect in the posterior fossa. Radical surgical resection was performed without morbidity. The patients were then treated by adjuvant radiochemotherapy with or without autologous peripheral blood stem cell transplantation, resulting in complete remission. Two patients developed extracranial recurrences 4 months after the treatments for intracranial metastases. One patient was treated by second high-dose chemotherapy with allo-geneic cord blood transplantation, again resulting in complete remission. Another patient was treated by second chemotherapy and maintaining stable disease. The other patient maintained complete remission. All three patients were alive without neurological deficit for 8, 11, and 12 months after diagnosis of brain metastasis. Patients with infratentorial brain metastases of highly malignant pediat-ric non-epithelial tumors are in a severe clinical state, but still can have longer and useful lives with aggressive multimodal treatments combined with radical surgical resection.

Original languageEnglish
Pages (from-to)167-174
Number of pages8
JournalBrain Tumor Pathology
Issue number2
Publication statusPublished - 2011 Apr


  • Brain metastasis
  • Neuroblastoma
  • Pediatric cancer
  • Rhabdomyosarcoma
  • Surgery

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research


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