Influenza project in Myanmar

Reiko Saito, Yadanar Kyaw, Yi Yi Myint, Clyde Dapat, Go Hasegawa, Makoto Naito

Research output: Contribution to journalReview articlepeer-review

Abstract

The epidemiological study of influenza in Southeast Asia is limited. We surveyed influenza in Myanmar from 2007 to 2013. Nasopharyngeal swabs were collected from patients in the two cities of Yangon and Nay Pyi Taw. Samples were screened using rapid influenza diagnostic kits and identified by virus isolation. Isolates were characterized by cyclingprobe-based real-time PCR, drug susceptibility assay, and sequencing. Samples collected numbered 5,173, from which 1,686 influenza viruses were isolated during the seven-year study period. Of these, 187 strains were of seasonal influenza A(H1N1), 274 of influenza A(H1N1)pdm09, 791 of influenza A(H3N2), and 434 of influenza B. Interestingly, two zanamivir and amantadine-resistant strains each were detected in 2007 and 2008. These rare dual-resistant strains had a Q136K mutation in the NA protein and S31N substitution in the M2 protein. Our collaboration raised the influenza surveillance laboratory capacity in Myanmar and led Yangon’s National Health Laboratory – one of the nation’s leading research institutes – to being designated a National Influenza Center by the World Health Organization.

Original languageEnglish
Pages (from-to)842-847
Number of pages6
JournalJournal of Disaster Research
Volume9
Issue number5
DOIs
Publication statusPublished - 2014 Oct 1

Keywords

  • Epidemiology
  • Influenza virus
  • Myanmar
  • Surveillance

ASJC Scopus subject areas

  • Safety, Risk, Reliability and Quality
  • Engineering (miscellaneous)

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