Influence of Uncertain Anticipation on Brain Responses to Aversive Rectal Distension in Patients with Irritable Bowel Syndrome

Michiko Kano, Tomohiko Muratsubaki, Joe Morishita, Keiji Kono, Shunji Mugikura, Kei Takase, Huynh Giao Ly, Patrick Dupont, Lukas Van Oudenhove, Shin Fukudo

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Objective We investigated whether certainty and uncertainty of impending aversive visceral sensation differently modulate regional brain activity, both during anticipation and visceral sensation in irritable bowel syndrome (IBS) patients compared with healthy controls. Methods Twenty-six IBS patients (14 women) and 29 healthy controls (15 women) were enrolled in a functional magnetic resonance imaging study. Participants received rectal distention at an individually titrated severe discomfort level that was preceded by visual cues to induce certain (100% chance of distention), uncertain (50% chance), and safe (0% chance) anticipation. Results Subjective ratings of anticipatory fear before and discomfort during distention were similar between IBS and control participants under cued certainty and uncertainty (p >.05). Uncertain anticipation compared with certain anticipation induced greater activation of anterior midcingulate cortex, thalamus, and visual processing areas in IBS patients compared with controls. Rectal distention after the uncertain, but not certain, cue induced higher activity in the posterior-and midcingulate cortices and the precuneus in IBS compared with controls. Controls exhibited bilateral insula activation during the nondistention period after the uncertain cue compared with the safe cue. IBS patients failed to produce this response, which was possibly due to elevated bilateral insular responses during nondistention after the safe cue. Brain data were significant at a voxel-level threshold of puncorrected value of less than.005 combined with a cluster-level threshold of pFWE-corrected value of less than.05. Conclusions Preceding uncertainty differentially modulates the brain processing of physiologically identical rectal stimulation in IBS patients. Cue-dependent alterations in brain responses may underlie hypervigilance to visceral sensations in IBS patients.

Original languageEnglish
Pages (from-to)988-999
Number of pages12
JournalPsychosomatic medicine
Volume79
Issue number9
DOIs
Publication statusPublished - 2017 Nov 1
Externally publishedYes

Keywords

  • anticipation
  • fMRI
  • safety signal
  • uncertainty
  • visceral stimulation

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Influence of Uncertain Anticipation on Brain Responses to Aversive Rectal Distension in Patients with Irritable Bowel Syndrome'. Together they form a unique fingerprint.

Cite this