TY - JOUR
T1 - Influence of previous abdominal surgery on surgical outcomes between laparoscopic and open surgery in elderly patients with colorectal cancer
T2 - subanalysis of a large multicenter study in Japan
AU - for the Japan Society of Laparoscopic Colorectal Surgery
AU - Yamamoto, Seiichiro
AU - Hinoi, Takao
AU - Niitsu, Hiroaki
AU - Okajima, Masazumi
AU - Ide, Yoshihito
AU - Murata, Kohei
AU - Akamoto, Shintaro
AU - Kanazawa, Akiyoshi
AU - Nakanishi, Masayoshi
AU - Naitoh, Takeshi
AU - Kanehira, Eiji
AU - Shimamura, Tsukasa
AU - Suzuka, Ichio
AU - Fukunaga, Yosuke
AU - Yamaguchi, Takashi
AU - Watanabe, Masahiko
AU - Shiozawa, Kunihisa
AU - Bando, Hiroyuki
AU - Yamamoto, Daisuke
AU - Kitano, Seigo
AU - Inomata, Masafumi
AU - Akagi, Tomonori
AU - Okuda, Junji
AU - Tanaka, Keitaro
AU - Yasui, Masayoshi
AU - Hirakawa, Kosei
AU - Maeda, Kiyoshi
AU - Hasegawa, Junichi
AU - Nishimura, Junichi
AU - Kuroyanagi, Hiroya
AU - Horie, Hisanaga
AU - Naito, Masaki
AU - Ueki, Takashi
AU - Sakai, Yoshiharu
AU - Hida, Koya
AU - Kinjo, Yousuke
AU - Kokuba, Yukihito
AU - Hamada, Madoka
AU - Saito, Norio
AU - Ito, Masaaki
AU - Yatsuoka, Toshimasa
AU - Tashiro, Jo
AU - Yamaguchi, Shigeki
AU - Furuhata, Tomohisa
AU - Okita, Kenji
AU - Kubo, Yoshiro
AU - Saito, Shuji
AU - Kinugasa, Yusuke
AU - Konishi, Fumio
AU - Sakamoto, Kazuhiro
N1 - Funding Information:
We appreciate the great advice provided by Minoru Hattori, Advanced Medical Skills Training Center, Hiroshima University, regarding the statistical analyses, and we owe our deepest gratitude to the following members of the Japan Society of Laparoscopic Colorectal Surgery for their cooperation: Kunihisa Shiozawa, Ageo Central General Hospital; Hiroyuki Bando, Daisuke Yamamoto, Ishikawa Prefectural Central Hospital; Seigo Kitano, Masafumi Inomata, Tomonori Akagi, Oita University; Junji Okuda, Keitaro Tanaka, Osaka Medical College; Masayoshi Yasui, Osaka National Hospital; Kosei Hirakawa, Kiyoshi Maeda, Osaka City University; Junichi Hasegawa, Junichi Nishimura, Osaka Rosai Hospital; Hiroya Kuroyanagi, Cancer Institute Hospital of JFCR; Hisanaga Horie, Jichi Medical University; Masaki Naito, Kitasato University; Takashi Ueki, Kyushu University; Yoshiharu Sakai, Koya Hida, Yousuke Kinjo, Kyoto University; Yukihito Kokuba, Kyoto Prefectural University; Madoka Hamada, Kochi Health Sciences Center; Norio Saito, Masaaki Ito, National Cancer Hospital East; Toshimasa Yatsuoka, Saitama Cancer Center; Jo Tashiro, Shigeki Yamaguchi, Saitama Medical University International Medical Center; Tomohisa Furuhata, Kenji Okita, Sapporo Medical University; Yoshiro Kubo, Shikoku Cancer Center; Shuji Saito, Yusuke Kinugasa, Shizuoka Cancer Center; Fumio Konishi, Saitama Medical Center Jichi Medical University; Kazuhiro Sakamoto, Michitoshi Goto, Juntendo University; Junichi Tanaka, Shungo Endo, Showa University Northern Yokohama Hospital; Nobuyoshi Miyajima, Tadashi Suda, St. Marianna University; Yoshihisa Saida, Toshiyuki Enomoto, Toho University Ohashi Medical Center; Yasuhiro Munakata, Ken Hayashi, Souichi Tagami, Nagano Municipal Hospital; Yasumasa Takii, Satoshi Maruyama, Niigata Cancer Center Hospital; Takao Ichihara, Nishinomiya Municipal Central Hospital; Hitoshi Idani, Kohei Kurose, Fukuyama Municipal Hospital; Yasuhiro Miyake, Minoh City Hospital; Shoichi Hazama, Yamaguchi University; Shoichi Fujii, Shigeru Yamagishi, Kazuteru Watanabe, Yokohama City University Medical Center; Kenichi Sugihara, Tokyo Medical and Dental University Graduate School, Shin Fujita, National Cancer Center Hospital. This study was supported by the Japanese Society for Cancer of the Colon and Rectum.
Publisher Copyright:
© 2016, Japanese Society of Gastroenterology.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Background: The aim of the present study was to examine the technical and oncological feasibility of laparoscopic surgery (LAP) in elderly patients with a history of abdominal surgery. Methods: We conducted a propensity score-matched case–control study of colorectal cancer (CRC) patients aged ≥80 years that were treated at 41 hospitals between 2003 and 2007. We included 601 patients who had a history of abdominal surgery and underwent curative and elective surgery for stage 0 to III CRC. After the matching procedure, 153 patients were included in each cohort. The surgical outcomes of LAP and open surgery (OS) were compared. P-values of <0.05 were considered statistically significant. Results: LAP resulted in a significantly longer surgical time (220 vs. 170 min, p < 0.001), but significantly less intraoperative blood loss (39 vs. 100 ml, p < 0.001). A number of postoperative recovery-related parameters, including the length of the hospitalization period (12 vs. 14 days, p = 0.002), and the days to the resumption of fluid (2 vs. 3 days, p < 0.001) and solid food intake (4 vs. 5 days, p < 0.001), were significantly better in the LAP group. Moreover, the overall morbidity rate (43 vs. 66 %, p = 0.009) and the frequency of postoperative ileus (7 vs. 19 %, p = 0.023) were significantly lower in the LAP group, while the frequencies of other morbidities did not differ significantly between the groups. In the survival analyses, overall survival and disease-free survival did not differ between the two groups. Conclusions: In this population, LAP can be performed safely in elderly CRC patients with a history of abdominal surgery, and LAP resulted in a lower postoperative morbidity rate than OS.
AB - Background: The aim of the present study was to examine the technical and oncological feasibility of laparoscopic surgery (LAP) in elderly patients with a history of abdominal surgery. Methods: We conducted a propensity score-matched case–control study of colorectal cancer (CRC) patients aged ≥80 years that were treated at 41 hospitals between 2003 and 2007. We included 601 patients who had a history of abdominal surgery and underwent curative and elective surgery for stage 0 to III CRC. After the matching procedure, 153 patients were included in each cohort. The surgical outcomes of LAP and open surgery (OS) were compared. P-values of <0.05 were considered statistically significant. Results: LAP resulted in a significantly longer surgical time (220 vs. 170 min, p < 0.001), but significantly less intraoperative blood loss (39 vs. 100 ml, p < 0.001). A number of postoperative recovery-related parameters, including the length of the hospitalization period (12 vs. 14 days, p = 0.002), and the days to the resumption of fluid (2 vs. 3 days, p < 0.001) and solid food intake (4 vs. 5 days, p < 0.001), were significantly better in the LAP group. Moreover, the overall morbidity rate (43 vs. 66 %, p = 0.009) and the frequency of postoperative ileus (7 vs. 19 %, p = 0.023) were significantly lower in the LAP group, while the frequencies of other morbidities did not differ significantly between the groups. In the survival analyses, overall survival and disease-free survival did not differ between the two groups. Conclusions: In this population, LAP can be performed safely in elderly CRC patients with a history of abdominal surgery, and LAP resulted in a lower postoperative morbidity rate than OS.
KW - Complication
KW - Elderly patients
KW - Laparoscopic colorectal surgery
KW - Matched case–control study
KW - Previous abdominal surgery
KW - Propensity scoring
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U2 - 10.1007/s00535-016-1262-5
DO - 10.1007/s00535-016-1262-5
M3 - Article
C2 - 27650199
AN - SCOPUS:84988643359
VL - 52
SP - 695
EP - 704
JO - Journal of Gastroenterology
JF - Journal of Gastroenterology
SN - 0944-1174
IS - 6
ER -