Influence of plaque stiffness on change of blood vessel geometry leading hemodynamical changes in PVA-H stenosis models

Yasutomo Shimizu, Shuya Shidam, Kenichi Funamoto, Toshiyuki Hayase, Makoto Ohta

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

One of the main factors affecting blood flow conditions in stenotic arteries is plaque geometry. Plaques can be deformed by the internal pressure, and hence plaque behavior varies depending on its stiffness. Blood flow pattern around a plaque is complicated by plaque behavior, and these complications may lead to growth of the plaque itself. Thus, we can say that geometry and mechanical properties of a plaque, and blood flow will affect each other. To understand the relationship between plaque stiffness and flow pattern, flow measurement using elastic models, which mimic the mechanical properties of blood vessels, is required. Flow patterns with steady flows and a range of hydrostatic pressures were observed by particle image velocimetry. The results show that the model is deformed by hydrostatic pressures. Furthermore, flow patterns are also changed as the results of model deformation, especially at reattachment points. Simultaneously, we performed a numerical simulation for finding a critical parameter of the flow patterns. These results show that the reattachment length increases in the model with high stenosis severity and in a vertically oriented parent artery. In conclusion, a parent artery and plaque can deform because of internal pressure, and these deformation will affect blood flow patterns.

Original languageEnglish
Title of host publicationASME 2012 International Mechanical Engineering Congress and Exposition, IMECE 2012
Pages455-460
Number of pages6
DOIs
Publication statusPublished - 2012 Dec 1
EventASME 2012 International Mechanical Engineering Congress and Exposition, IMECE 2012 - Houston, TX, United States
Duration: 2012 Nov 92012 Nov 15

Publication series

NameASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
Volume2

Other

OtherASME 2012 International Mechanical Engineering Congress and Exposition, IMECE 2012
CountryUnited States
CityHouston, TX
Period12/11/912/11/15

ASJC Scopus subject areas

  • Mechanical Engineering

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  • Cite this

    Shimizu, Y., Shidam, S., Funamoto, K., Hayase, T., & Ohta, M. (2012). Influence of plaque stiffness on change of blood vessel geometry leading hemodynamical changes in PVA-H stenosis models. In ASME 2012 International Mechanical Engineering Congress and Exposition, IMECE 2012 (pp. 455-460). (ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE); Vol. 2). https://doi.org/10.1115/IMECE2012-87073