Influence of intramedullary stress on cervical spondylotic myelopathy

K. Takahashi, H. Ozawa, N. Sakamoto, Y. Minegishi, M. Sato, E. Itoi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Study design:A cross-sectional analysis.Objective:To examine whether intramedullary stress is related to the appearance of symptoms in cervical spondylotic myelopathy (CSM).Setting:Japan.Methods:Thirty-three consecutive patients with CSM and 30 consecutive patients without CSM were enrolled. A total of 99 disc levels from C3 to C6 in 33 patients with CSM were divided into two groups: 33 disc levels with high signal intensity (HSI) on T2-weighted magnetic resonance image (HSI group) and 66 disc levels without HSI (Non-HSI group). Ninety disc levels from C3 to C6 in patients without CSM were set up in a control group. Intramedullary stress value at each level was analyzed using the finite element method. Stress was compared among the three groups. A cutoff value of stress to present HSI was investigated from receiver operator characteristics (ROC) curve.Results:In all the patients with CSM, the disc level with HSI presented the highest stress among the three disc levels evaluated. The stress was 3.16±0.86 kPa (mean±s.d.) in the HSI group, 1.81±0.72 kPa in the Non-HSI group and 1.01±0.37 kPa in the control group. The stress differed significantly among the three groups (P<0.0001). The qualified cutoff value derived from the ROC curve was 2.30 kPa (sensitivity 78.8%, specificity 91.9%). None of the disc levels in the control group exceeded 2.30 kPa.Conclusion:HSI was strongly associated with intramedullary stress. Threshold of intramedullary stress to present HSI that related closely to the symptoms of myelopathy was revealed.

Original languageEnglish
Pages (from-to)761-764
Number of pages4
JournalSpinal cord
Volume51
Issue number10
DOIs
Publication statusPublished - 2013 Oct

Keywords

  • Cervical myelopathy
  • Finite element method
  • High signal intensity
  • Intramedullary stress

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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