Influence of experimental esophageal acidification on sleep bruxism: A randomized trial

H. Ohmure, K. Oikawa, K. Kanematsu, Y. Saito, T. Yamamoto, H. Nagahama, H. Tsubouchi, S. Miyawaki

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)


The aim of this cross-over, randomized, single-blinded trial was to examine whether intra-esophageal acidification induces sleep bruxism (SB). Polysomnography with electromyogram (EMG) of masseter muscle, audio-video recording, and esophageal pH monitoring were performed in a sleep laboratory. Twelve healthy adult males without SB participated. Intra-esophageal infusions of 5-mL acidic solution (0.1 N HCl) or saline were administered. The frequencies of EMG bursts, rhythmic masticatory muscle activity (RMMA) episodes, grinding noise, and the RMMA/microarousal ratio were significantly higher in the 20-minute period after acidic infusion than after saline infusion. RMMA episodes including SB were induced by esophageal acidification. This trial is registered with the UMIN Clinical Trials Registry, UMIN000002923. Abbreviations: ASDA, American Sleep Disorders Association; EMG, electromyogram; GER, gastroesophageal reflux; LES, lower esophageal sphincter; NREM, non-rapid eye movement; REM, rapid eye movement; RMMA, rhythmic masticatory muscle activity; SB, sleep bruxism; SD, standard deviation; UES, upper esophageal sphincter.

Original languageEnglish
Pages (from-to)665-671
Number of pages7
JournalJournal of dental research
Issue number5
Publication statusPublished - 2011 May


  • acid infusion
  • esophagus
  • gastroesophageal reflux
  • rhythmic masticatory muscle activity
  • sleep bruxism

ASJC Scopus subject areas

  • Dentistry(all)


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