TY - JOUR
T1 - Influence of experimental esophageal acidification on sleep bruxism
T2 - A randomized trial
AU - Ohmure, H.
AU - Oikawa, K.
AU - Kanematsu, K.
AU - Saito, Y.
AU - Yamamoto, T.
AU - Nagahama, H.
AU - Tsubouchi, H.
AU - Miyawaki, S.
N1 - Funding Information:
This study was supported by Grants-in-Aid for Scientific Research (20592409, 20390524) from the Japan Society for the Promotion of Science.
PY - 2011/5
Y1 - 2011/5
N2 - The aim of this cross-over, randomized, single-blinded trial was to examine whether intra-esophageal acidification induces sleep bruxism (SB). Polysomnography with electromyogram (EMG) of masseter muscle, audio-video recording, and esophageal pH monitoring were performed in a sleep laboratory. Twelve healthy adult males without SB participated. Intra-esophageal infusions of 5-mL acidic solution (0.1 N HCl) or saline were administered. The frequencies of EMG bursts, rhythmic masticatory muscle activity (RMMA) episodes, grinding noise, and the RMMA/microarousal ratio were significantly higher in the 20-minute period after acidic infusion than after saline infusion. RMMA episodes including SB were induced by esophageal acidification. This trial is registered with the UMIN Clinical Trials Registry, UMIN000002923. Abbreviations: ASDA, American Sleep Disorders Association; EMG, electromyogram; GER, gastroesophageal reflux; LES, lower esophageal sphincter; NREM, non-rapid eye movement; REM, rapid eye movement; RMMA, rhythmic masticatory muscle activity; SB, sleep bruxism; SD, standard deviation; UES, upper esophageal sphincter.
AB - The aim of this cross-over, randomized, single-blinded trial was to examine whether intra-esophageal acidification induces sleep bruxism (SB). Polysomnography with electromyogram (EMG) of masseter muscle, audio-video recording, and esophageal pH monitoring were performed in a sleep laboratory. Twelve healthy adult males without SB participated. Intra-esophageal infusions of 5-mL acidic solution (0.1 N HCl) or saline were administered. The frequencies of EMG bursts, rhythmic masticatory muscle activity (RMMA) episodes, grinding noise, and the RMMA/microarousal ratio were significantly higher in the 20-minute period after acidic infusion than after saline infusion. RMMA episodes including SB were induced by esophageal acidification. This trial is registered with the UMIN Clinical Trials Registry, UMIN000002923. Abbreviations: ASDA, American Sleep Disorders Association; EMG, electromyogram; GER, gastroesophageal reflux; LES, lower esophageal sphincter; NREM, non-rapid eye movement; REM, rapid eye movement; RMMA, rhythmic masticatory muscle activity; SB, sleep bruxism; SD, standard deviation; UES, upper esophageal sphincter.
KW - acid infusion
KW - esophagus
KW - gastroesophageal reflux
KW - rhythmic masticatory muscle activity
KW - sleep bruxism
UR - http://www.scopus.com/inward/record.url?scp=79955863961&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955863961&partnerID=8YFLogxK
U2 - 10.1177/0022034510393516
DO - 10.1177/0022034510393516
M3 - Article
C2 - 21248360
AN - SCOPUS:79955863961
VL - 90
SP - 665
EP - 671
JO - Journal of Dental Research
JF - Journal of Dental Research
SN - 0022-0345
IS - 5
ER -