Influence of anesthesia on brain distribution of [11C]methamphetamine in monkeys in positron emission tomography (PET) study

Michinao Mizugaki, Naoto Nakagawa, Hitoshi Nakamura, Takanori Hishinuma, Yoshihisa Tomioka, Shunji Ishiwata, Tatsuo Ido, Ren Iwata, Yoshihito Funaki, Masatoshi Itoh, Masato Higuchi, Nobuyuki Okamura, Takehiko Fujiwara, Mitsutomo Sato, Katsuhiro Shindo, Sumiko Yoshida

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

We investigated the influence of anesthesia on the brain distribution of [11C]methamphetamine (MAP) obtained by the positron emission tomography (PET) using the normal rhesus monkeys. We clarified that the brain uptake of [11C]MAP under halothane anesthesia was faster and higher than that under pentobarbital. The difference of the effect of anesthesia is an important problem in pharmacokinetic study in PET with experimental animals.

Original languageEnglish
Pages (from-to)173-175
Number of pages3
JournalBrain research
Volume911
Issue number2
DOIs
Publication statusPublished - 2001 Aug 24
Externally publishedYes

Keywords

  • Halothane
  • Methamphetamine
  • PET
  • Pentobarbital
  • Sensitization

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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