Influence of anesthesia on brain distribution of [11C]methamphetamine in monkeys in positron emission tomography (PET) study

Michinao Mizugaki; Naoto Nakagawa; Hitoshi Nakamura; Takanori Hishinuma; Yoshihisa Tomioka; Shunji Ishiwata; Tatsuo Ido; Ren Iwata; Yoshihito Funaki; Masatoshi Itoh; Masato Higuchi; Nobuyuki Okamura; Takehiko Fujiwara; Mitsutomo Sato; Katsuhiro Shindo; Sumiko Yoshida

doi:10.1016/S0006-8993(01)02669-5

Influence of anesthesia on brain distribution of [¹¹C]methamphetamine in monkeys in positron emission tomography (PET) study

Michinao Mizugaki, Naoto Nakagawa, Hitoshi Nakamura, Takanori Hishinuma, Yoshihisa Tomioka, Shunji Ishiwata, Tatsuo Ido, Ren Iwata, Yoshihito Funaki, Masatoshi Itoh, Masato Higuchi, Nobuyuki Okamura, Takehiko Fujiwara, Mitsutomo Sato, Katsuhiro Shindo, Sumiko Yoshida

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

We investigated the influence of anesthesia on the brain distribution of [¹¹C]methamphetamine (MAP) obtained by the positron emission tomography (PET) using the normal rhesus monkeys. We clarified that the brain uptake of [¹¹C]MAP under halothane anesthesia was faster and higher than that under pentobarbital. The difference of the effect of anesthesia is an important problem in pharmacokinetic study in PET with experimental animals.

Original language	English
Pages (from-to)	173-175
Number of pages	3
Journal	Brain research
Volume	911
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(01)02669-5
Publication status	Published - 2001 Aug 24
Externally published	Yes

Keywords

Halothane
Methamphetamine
PET
Pentobarbital
Sensitization

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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Mizugaki, M., Nakagawa, N., Nakamura, H., Hishinuma, T., Tomioka, Y., Ishiwata, S., Ido, T., Iwata, R., Funaki, Y., Itoh, M., Higuchi, M., Okamura, N., Fujiwara, T., Sato, M., Shindo, K., & Yoshida, S. (2001). Influence of anesthesia on brain distribution of [¹¹C]methamphetamine in monkeys in positron emission tomography (PET) study. Brain research, 911(2), 173-175. https://doi.org/10.1016/S0006-8993(01)02669-5

Influence of anesthesia on brain distribution of [¹¹C]methamphetamine in monkeys in positron emission tomography (PET) study. / Mizugaki, Michinao; Nakagawa, Naoto; Nakamura, Hitoshi; Hishinuma, Takanori; Tomioka, Yoshihisa; Ishiwata, Shunji; Ido, Tatsuo; Iwata, Ren; Funaki, Yoshihito ; Itoh, Masatoshi; Higuchi, Masato; Okamura, Nobuyuki; Fujiwara, Takehiko; Sato, Mitsutomo; Shindo, Katsuhiro; Yoshida, Sumiko.

In: Brain research, Vol. 911, No. 2, 24.08.2001, p. 173-175.

Research output: Contribution to journal › Article › peer-review

Mizugaki, M, Nakagawa, N, Nakamura, H, Hishinuma, T, Tomioka, Y, Ishiwata, S, Ido, T, Iwata, R, Funaki, Y , Itoh, M, Higuchi, M, Okamura, N, Fujiwara, T, Sato, M, Shindo, K & Yoshida, S 2001, 'Influence of anesthesia on brain distribution of [¹¹C]methamphetamine in monkeys in positron emission tomography (PET) study', Brain research, vol. 911, no. 2, pp. 173-175. https://doi.org/10.1016/S0006-8993(01)02669-5

Mizugaki, Michinao ; Nakagawa, Naoto ; Nakamura, Hitoshi ; Hishinuma, Takanori ; Tomioka, Yoshihisa ; Ishiwata, Shunji ; Ido, Tatsuo ; Iwata, Ren ; Funaki, Yoshihito ; Itoh, Masatoshi ; Higuchi, Masato ; Okamura, Nobuyuki ; Fujiwara, Takehiko ; Sato, Mitsutomo ; Shindo, Katsuhiro ; Yoshida, Sumiko. / Influence of anesthesia on brain distribution of [¹¹C]methamphetamine in monkeys in positron emission tomography (PET) study. In: Brain research. 2001 ; Vol. 911, No. 2. pp. 173-175.

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title = "Influence of anesthesia on brain distribution of [11C]methamphetamine in monkeys in positron emission tomography (PET) study",

abstract = "We investigated the influence of anesthesia on the brain distribution of [11C]methamphetamine (MAP) obtained by the positron emission tomography (PET) using the normal rhesus monkeys. We clarified that the brain uptake of [11C]MAP under halothane anesthesia was faster and higher than that under pentobarbital. The difference of the effect of anesthesia is an important problem in pharmacokinetic study in PET with experimental animals.",

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note = "Funding Information: We are grateful of the PET stuffs of the Cyclotron and Radioisotope Center, Tohoku University, for their cooperation. A part of this research was supported by a Grants-in-Aid for Scientific Research B (# 12557227) from the Ministry of Education, Culture, Sports, Science and Technology of the Japanese Government. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.",

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AU - Hishinuma, Takanori

AU - Tomioka, Yoshihisa

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AU - Ido, Tatsuo

AU - Iwata, Ren

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AU - Itoh, Masatoshi

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AU - Okamura, Nobuyuki

AU - Fujiwara, Takehiko

AU - Sato, Mitsutomo

AU - Shindo, Katsuhiro

AU - Yoshida, Sumiko

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PY - 2001/8/24

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