TY - JOUR
T1 - Influence of aging on periodontal regenerative therapy using enamel matrix derivative
T2 - A 3-year prospective cohort study
AU - Mikami, Risako
AU - Mizutani, Koji
AU - Shioyama, Hidehiro
AU - Matsuura, Takanori
AU - Aoyama, Norio
AU - Suda, Tomonari
AU - Kusunoki, Yukako
AU - Takeda, Kohei
AU - Izumi, Yuichi
AU - Aida, Jun
AU - Aoki, Akira
AU - Iwata, Takanori
N1 - Funding Information:
This work was supported by a Grant‐in‐Aid for Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (grant number 20K18497 to Risako Mikami and 19K10125 to Koji Mizutani). Funding information
Funding Information:
The authors thank the staff of Department of Periodontology of TMDU for their assistance with data collection.
Publisher Copyright:
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
PY - 2022/2
Y1 - 2022/2
N2 - Aim: To investigate the influence of chronological aging on periodontal regenerative therapy (PRT) outcomes with enamel matrix derivative (EMD). Materials and Methods: In total, 253 intra-bony defects (151 patients) including 44 furcation involvement were prospectively investigated for 3 years after regenerative therapy with EMD by evaluating probing pocket depth (PPD), clinical attachment level (CAL), and radiographic bone defect depth (RBD). The influence of age on these outcomes was assessed using multilevel regression analyses adjusting for confounders. Results: Participants' mean age was 55.9 ± 12.3 years (range: 22–85). Baseline PPD, CAL, and RBD were 6.14 ± 1.82, 7.22 ± 2.14, and 5.08 ± 2.04 mm, respectively. Significant improvement was observed with PPD reductions of 2.84 ± 1.73 and 2.87 ± 1.87 mm, CAL gains of 2.40 ± 1.87 and 2.47 ± 1.89 mm, and RBD gains of 1.76 ± 1.98 and 2.39 ± 2.41 mm at 1- and 3-year examinations, respectively. At the 1-year examination, multivariate analysis revealed a significant negative association between age and improvement in PPD and CAL (coefficients: −0.13, −0.23 mm per 10 years). However, by the 3-year examination, no significant association was noted between age and improvement in PPD, CAL, or RBD. Conclusion: Although the statistical difference was detected with age at 1-year examination, PRT with EMD significantly improved clinical outcomes on long-term observation, irrespective of the patient's age. Clinical trial registration number: UMIN000039846.
AB - Aim: To investigate the influence of chronological aging on periodontal regenerative therapy (PRT) outcomes with enamel matrix derivative (EMD). Materials and Methods: In total, 253 intra-bony defects (151 patients) including 44 furcation involvement were prospectively investigated for 3 years after regenerative therapy with EMD by evaluating probing pocket depth (PPD), clinical attachment level (CAL), and radiographic bone defect depth (RBD). The influence of age on these outcomes was assessed using multilevel regression analyses adjusting for confounders. Results: Participants' mean age was 55.9 ± 12.3 years (range: 22–85). Baseline PPD, CAL, and RBD were 6.14 ± 1.82, 7.22 ± 2.14, and 5.08 ± 2.04 mm, respectively. Significant improvement was observed with PPD reductions of 2.84 ± 1.73 and 2.87 ± 1.87 mm, CAL gains of 2.40 ± 1.87 and 2.47 ± 1.89 mm, and RBD gains of 1.76 ± 1.98 and 2.39 ± 2.41 mm at 1- and 3-year examinations, respectively. At the 1-year examination, multivariate analysis revealed a significant negative association between age and improvement in PPD and CAL (coefficients: −0.13, −0.23 mm per 10 years). However, by the 3-year examination, no significant association was noted between age and improvement in PPD, CAL, or RBD. Conclusion: Although the statistical difference was detected with age at 1-year examination, PRT with EMD significantly improved clinical outcomes on long-term observation, irrespective of the patient's age. Clinical trial registration number: UMIN000039846.
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U2 - 10.1111/jcpe.13552
DO - 10.1111/jcpe.13552
M3 - Article
C2 - 34545600
AN - SCOPUS:85117785927
VL - 49
SP - 123
EP - 133
JO - Journal of Clinical Periodontology
JF - Journal of Clinical Periodontology
SN - 0303-6979
IS - 2
ER -