Infliximab-induced tubulointerstitial nephritis with image findings of striated nephrogram in Crohn’s disease

Tomonori Sato, Yoshihide Kawasaki, Akihiro Ito, Hideaki Izumi, Naoki Kawamorita, Shinichi Yamashita, Koji Mitsuzuka, Tomonori Matsuura, Mika Watanabe, Yoichi Arai

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Tubulointerstitial nephritis is primary injury to renal tubules and interstititum which could be resulting in decreased renal function. The acute and chronic forms are most often due to allergic drug reactions or to infections. Tubulointerstitial nephritis in Crohn’s disease has rarely been reported. Imaging findings of a striated nephrogram on enhanced computed tomography (CT) could represent the clinical state of tubulointerstitial nephritis. This is the first report of tubulointerstitial nephritis caused by infliximab, monoclonal antibody against human tumor necrosis factor-α, showing striated nephrograms in Crohn’s disease. The case of a 28-year-old man treated with infliximab for Crohn’s disease is described. Infliximab was added to his maintenance therapy, and bowel symptoms were stable. The patient presented with a 2-month history of fever and an elevated C-reactive protein after infliximab administration for 4.5 years. Contrast-enhanced CT showed striated nephrograms in both kidneys. Urinalysis showed no abnormal findings. The pathological diagnosis on CT-guided percutaneous renal needle biopsy was drug-induced tubulointerstitial nephritis because of eosinophilic infiltration with neutrophils mainly in the tubulointerstitial areas. The imaging findings of striated nephrogram are important for the diagnosis of tubulointerstitial nephritis. Tubulointerstitial nephritis could be caused by drug-induced inflammation or direct extension of Crohn’s disease as an extra-interstitial manifestation. The treatment strategies for these two diseases are contradictory to each other and inappropriate treatment could worsen the renal function. Needle biopsy is therefore indispensable for differential diagnosis.

Original languageEnglish
Pages (from-to)149-152
Number of pages4
JournalTohoku Journal of Experimental Medicine
Volume245
Issue number3
DOIs
Publication statusPublished - 2018 Jul

Keywords

  • Crohn’s disease
  • Infliximab
  • Renal biopsy
  • Striated nephrogram
  • Tubulointerstitial nephritis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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