Inflammatory reactions in extraoral tissues in mice after intragingival injection of lipopolysaccharide

Hiromi Funayama, Hideaki Mayanagi, Haruhiko Takada, Yasuo Endo

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Intragingival (ig) injection into mice of lipopolysaccharide (LPS) from Prevotella intermedia or Escherichia coli elevated the activity of the histamine-forming enzyme, histidine decarboxylase (HDC), in the mandible, liver, lung, and spleen, with a time course similar to that seen with intravenous (iv) injection. The effect of ig injection was less than that of iv injection but similar to that of intraperitoneal (ip) injection. The ig injection also increased hepatic serotonin, reflecting platelet accumulation. In galactosamine-treated mice, the minimum ig dose of LPS needed to induce lethal hepatitis was very small (less than that needed by ip injection). These results support the idea that the LPS produced in oral tissues may be transported easily to extraoral tissues and, in some cases, may cause inflammatory or immune responses. It also may influence the pathogenesis of some systemic diseases.

Original languageEnglish
Pages (from-to)1566-1571
Number of pages6
JournalJournal of Infectious Diseases
Issue number12
Publication statusPublished - 2001 Dec 15
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


Dive into the research topics of 'Inflammatory reactions in extraoral tissues in mice after intragingival injection of lipopolysaccharide'. Together they form a unique fingerprint.

Cite this