Infiltration of T lymphocytes and expression of ICAM-1 in the hippocampus of patients with hippocampal sclerosis

Hiroaki Nakahara, Yoshihiro Konishi, Thomas G. Beach, Naoto Yamada, Satoshi Makino, Ikuo Tooyama

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


200W? eT hae nJdap aonth Seorcsi ehtya voef Hpirsetovciohuemsliys trsyh aonwdn C tyh-at reactive microglia express the major histocompatibility complex (MHC) class I and class II antigens in the hippocampus of patients suffering from epilepsy. Although the MHC glycoproteins serve as restriction elements for T lymphocytes, there is little information available regarding T lymphocytes in hippocampal sclerosis. In the present study, we investigated T lymphocyte infiltration in human hippocampi in four cases of epilepsy with hippocampal sclerosis, as well as in four control cases without neurological disease. No CD8- or CD4-positive T lymphocytes were seen in hippocampi from the control cases. In contrast, CD8- and CD4-positive T lymphocytes had infiltrated into the hippocampi of patients with hippocampal sclerosis. In addition, expression of intercellular adhesion molecule-1 was diffusely upregulated in the hippocampi with hippocampal sclerosis. These results indicate that T lymphocyte infiltration is involved in the pathology of hippocampal sclerosis.

Original languageEnglish
Pages (from-to)157-162
Number of pages6
Issue number6
Publication statusPublished - 2010
Externally publishedYes


  • Epilepsy
  • Hippocampus
  • Lymphocyte
  • Microglia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Biochemistry
  • Physiology
  • Histology
  • Cell Biology


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