Infiltration of CD14-positive macrophages at the invasive front indicates a favorable prognosis in colorectal cancer patients with lymph node metastasis

Makoto Kinouchi, Koh Miura, Takayuki Mizoi, Kazuyuki Ishida, Wataru Fujibuchi, Toshinori Ando, Nobuki Yazaki, Kazuya Saito, Ken Ichi Shiiba, Iwao Sasaki

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Background/Aims: To clarify the distribution of CD14+ macrophages in colorectal cancer using flow cytometry and immunohistochemistry, and to elucidate the roles of CD14+ macrophages in colorectal cancer. Methodology: We studied the paired cancerous and corresponding normal tissues from 52 patients with colorectal cancer for the distribution of CD14 +, CD1a+, CD83+ and CD68+ cells, and correlated the findings with the clinicopathological characteristics and with the expression of CD86 and CD80 in the CD14+ macrophages, which are co-stimulatory factors for T cell activation. Results: 1) CD14+ macrophages were distributed predominantly at the invasive front of colorectal cancer tissues, rather than in the normal tissues, 2) a high percentage of the CD14+ macrophages expressed CD86 and CD80, and 3) in the colorectal cancer cases with lymph node metastasis, the 5-year overall survival rate of the high CD14 group, in which the number of CD14+ macrophages was higher than the median, was better than that of the low CD14 group. Conclusion: The infiltration of CD14+ macrophages at the invasive front indicates a favorable prognosis in colorectal cancer patients with lymph node metastasis. In addition, the activation of CD14+ macrophages and T cells may facilitate the development of new immunotherapeutic strategies for colorectal cancer patients.

Original languageEnglish
Pages (from-to)352-358
Number of pages7
JournalHepato-Gastroenterology
Volume58
Issue number106
Publication statusPublished - 2011 Mar

Keywords

  • CD14
  • Colorectal cancer
  • Flow cytometry
  • Immunohistochemistry
  • Macrophage

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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