Inference of gene regulation via miRNAs during ES cell differentiation using MiRaGE method

Masato Yoshizawa; Y. h. Taguchi; Jun Yasuda

doi:10.3390/ijms12129265

Inference of gene regulation via miRNAs during ES cell differentiation using MiRaGE method

Masato Yoshizawa, Y. h. Taguchi, Jun Yasuda

Tohoku Medical Megabank Organization (ToMMo)

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

MicroRNA (miRNA) is a critical regulator of cell growth, differentiation, and development. To identify important miRNAs in a biological process, many bioinformatical tools have been developed. We have developed MiRaGE (MiRNA Ranking by Gene Expression) method to infer the regulation of gene expression by miRNAs from changes of gene expression profiles. The method does not require precedent array normalization. We applied the method to elucidate possibly important miRNAs during embryonic stem (ES) cell differentiation to neuronal cells and we infer that certain miRNAs, including miR-200 family, miR-429, miR-302 family, and miR-17-92 cluster members may be important to the maintenance of undifferentiated status in ES cells.

Original language	English
Pages (from-to)	9265-9276
Number of pages	12
Journal	International journal of molecular sciences
Volume	12
Issue number	12
DOIs	https://doi.org/10.3390/ijms12129265
Publication status	Published - 2011 Dec

Keywords

Embryonic stem cell
MIRaGE metheod
MiRNA

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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abstract = "MicroRNA (miRNA) is a critical regulator of cell growth, differentiation, and development. To identify important miRNAs in a biological process, many bioinformatical tools have been developed. We have developed MiRaGE (MiRNA Ranking by Gene Expression) method to infer the regulation of gene expression by miRNAs from changes of gene expression profiles. The method does not require precedent array normalization. We applied the method to elucidate possibly important miRNAs during embryonic stem (ES) cell differentiation to neuronal cells and we infer that certain miRNAs, including miR-200 family, miR-429, miR-302 family, and miR-17-92 cluster members may be important to the maintenance of undifferentiated status in ES cells.",

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AU - Taguchi, Y. h.

AU - Yasuda, Jun

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AB - MicroRNA (miRNA) is a critical regulator of cell growth, differentiation, and development. To identify important miRNAs in a biological process, many bioinformatical tools have been developed. We have developed MiRaGE (MiRNA Ranking by Gene Expression) method to infer the regulation of gene expression by miRNAs from changes of gene expression profiles. The method does not require precedent array normalization. We applied the method to elucidate possibly important miRNAs during embryonic stem (ES) cell differentiation to neuronal cells and we infer that certain miRNAs, including miR-200 family, miR-429, miR-302 family, and miR-17-92 cluster members may be important to the maintenance of undifferentiated status in ES cells.

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