Inference of gene expression regulation via microRNA transfection

Y. H. Taguchi, Jun Yasuda

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

How each microRNA regulates gene expression is unknown problem. Especially, which gene is targeted by each microRNA is mainly depicted via computational method, typically without biological/ experimental validations. In this paper, we propose a computational method to detect gene expression regulation via miRNAs by the use of expression profile data and miRNA target prediction. This method is tested to miRNA transfection experiments to tumor cells and succeeded in inference of transfected miRNA.

Original languageEnglish
Title of host publicationAdvanced Intelligent Computing Theories and Applications - 6th International Conference on Intelligent Computing, ICIC 2010, Proceedings
Pages672-679
Number of pages8
DOIs
Publication statusPublished - 2010
Event6th International Conference on Intelligent Computing, ICIC 2010 - Changsha, China
Duration: 2010 Aug 182010 Aug 21

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume6215 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other6th International Conference on Intelligent Computing, ICIC 2010
CountryChina
CityChangsha
Period10/8/1810/8/21

Keywords

  • computational inference
  • microRNA
  • target genes
  • tumor

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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