Infectivity and arthritis induction of Borrelia japonica on SCID mice and immune competent mice: Possible role of galactosylceramide binding activity on initiation of infection

Kazuhide Kaneda, Toshiyuki Masuzawa, Markus M. Simon, Emiko Isogai, Hiroshi Isogai, Kitsuzo Yasugami, Takashi Suzuki, Yasuo Suzuki, Yasutake Yanagihara

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    We investigated the relationship between the binding activity to galactosylceramide (GalCer) and the arthritis induction activity of Borrelia japonica. The B. japonica strains maintained the ability to induce arthritis in inbred C3H/HeN and immunodeficient SCID mice, but the ability was lower than that of Borrelia burgdorferi sensu stricto virulent strain 297. Histopathological changes were restricted to the joints and a marked effusion of polymorphonuclear neutrophils into the joint space was found. The binding activity of B. japonica strains to GalCer was lower than that of the virulent strain 297 but higher than that of the high-passage strain 297. The lower infectivity and virulence of B. japonica may explain its lower binding ability to GalCer.

    Original languageEnglish
    Pages (from-to)171-175
    Number of pages5
    JournalMICROBIOLOGY and IMMUNOLOGY
    Volume42
    Issue number3
    DOIs
    Publication statusPublished - 1998

    Keywords

    • Borrelia japonica
    • Galactosylceramide
    • Infectivity
    • Lyme disease
    • SCID mice

    ASJC Scopus subject areas

    • Microbiology
    • Immunology
    • Virology

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