TY - JOUR
T1 - Induction of Tac antigen and proliferation of myeloid leukemic cells by ATL-derived factor
T2 - Comparison with other agents that promote differentiation of human myeloid or monocytic leukemic cells
AU - Yamamoto, S.
AU - Hattori, T.
AU - Matsuoka, M.
AU - Ishii, T.
AU - Asou, N.
AU - Okada, M.
AU - Tagaya, Y.
AU - Yodoi, J.
AU - Takatsuki, K.
PY - 1986
Y1 - 1986
N2 - We studied seven cases of myeloid leukemia at various differentiation stages to investigate the response of leukemic cells to phorbol 12-myristate 13-acetate (PMA) and various biological factors. γ-Interferon (γ-IFN)-treated cells expressed higher amounts of Fc receptors on leukemic cells in five out of seven cases. Expression of HLA-DR antigen of γ-IFN-treated leukemic cells was significantly enhanced in three cases. PMA did not induce Fc receptors or HLA-DR antigen on these cells. Induction of Tac antigen, a putative interleukin 2 (IL 2) receptor, was observed in two cases after cultivation with PMA or with a novel lymphokine, adult T cell leukemia-derived factor (ADF). Cells from one of these patients expressed Tac antigen immediately after cell separation, and expression of Tac antigen was augmented by PMA and ADF. Interleukin 1 (IL 1) or IL 2 did not induce Tac antigen. Leukemic cells from this patient also proliferated vigorously in th presence of ADF but not PMA, IL 1, or IL 2.
AB - We studied seven cases of myeloid leukemia at various differentiation stages to investigate the response of leukemic cells to phorbol 12-myristate 13-acetate (PMA) and various biological factors. γ-Interferon (γ-IFN)-treated cells expressed higher amounts of Fc receptors on leukemic cells in five out of seven cases. Expression of HLA-DR antigen of γ-IFN-treated leukemic cells was significantly enhanced in three cases. PMA did not induce Fc receptors or HLA-DR antigen on these cells. Induction of Tac antigen, a putative interleukin 2 (IL 2) receptor, was observed in two cases after cultivation with PMA or with a novel lymphokine, adult T cell leukemia-derived factor (ADF). Cells from one of these patients expressed Tac antigen immediately after cell separation, and expression of Tac antigen was augmented by PMA and ADF. Interleukin 1 (IL 1) or IL 2 did not induce Tac antigen. Leukemic cells from this patient also proliferated vigorously in th presence of ADF but not PMA, IL 1, or IL 2.
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U2 - 10.1182/blood.v67.6.1714.1714
DO - 10.1182/blood.v67.6.1714.1714
M3 - Article
C2 - 3011152
AN - SCOPUS:0022495671
SN - 0006-4971
VL - 67
SP - 1714
EP - 1720
JO - Blood
JF - Blood
IS - 6
ER -