Induction of Rat Pancreatic B-Cell Tumors by the Combined Administration of Streptozotocin or Alloxan and Poly(Adenosine Diphosphate Ribose) Synthetase Inhibitors

Takashi Yamagami, Atsuo Miwa, Shin Takasawa, Hiroshi Yamamoto, Hiroshi Okamoto

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)

Abstract

Streptozotocin and alloxan were administered to Wistar rats in combination with poly(adenosine diphosphate ribose) synthetase inhibitors. Ten to 16 months after the injection of streptozotocin (50 mg/kg body weight i.v.) and 3-aminobenzamide (345 mg/kg i.v.), streptozotocin (50 mg/kg) and nicotinamide (350 mg/ kg i.p.), streptozotocin (50 mg/kg) and picolinamide (250 mg/kg i.p.), alloxan (40 mg/kg i.v.) and nicotinamide (350 mg/kg), alloxan (40 mg/kg) and 3-aminobenzamide (345 mg/kg), and alloxan (40 mg/kg) and picolinamide (250 mg/kg), pancreatic islet cell tumors developed in 100, 98, 60, 26, 22, and 20% of surviving rats, respectively. However, after the single injection of streptozotocin and alloxan, islet cell tumors developed in 42 and 11% of surviving rats, respectively. The tumors were rich in B-granules on electron micrographs and contained as large amounts of proinsulin messenger RNA as normal pancreatic islets. The results indicate that poly(adenosine diphosphate ribose) synthetase inhibitors enhance the tumorigenic effect of streptozotocin and alloxan on islet B-cells.

Original languageEnglish
Pages (from-to)1845-1849
Number of pages5
JournalCancer Research
Volume45
Issue number4
Publication statusPublished - 1985 Apr 1
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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