Induction of polysialic acid-neural cell adhesion molecule in surviving motoneurons of transgenic amyotrophic lateral sclerosis mice

Hitoshi Warita, Tetsuro Murakami, Yasuhiro Manabe, Keiko Sato, Takeshi Hayashi, Tatsunori Seki, Koji Abe

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The highly polysialylated neural cell adhesion molecule (PSA-NCAM) is recognized as a marker of neurogenesis or neural plasticity in adult nervous system. PSA-NCAM expression was examined in the spinal cord of transgenic mice harboring a mutant Cu/Zn superoxide dismutase (SOD1) gene. Immunohistochemistry showed a progressive expression of PSA-NCAM in surviving motoneurons of spinal ventral horns from an early and presymptomatic stage (25 weeks) before significant loss of ventral horn neurons, while no detectable PSA-NCAM in the ventral horn of non-transgenic littermates during the ageing process. The present data suggest that a specific expression of PSA-NCAM may be involved in the survival of spinal motoneurons under pathological conditions such as amyotrophic lateral sclerosis.

Original languageEnglish
Pages (from-to)75-78
Number of pages4
JournalNeuroscience Letters
Volume300
Issue number2
DOIs
Publication statusPublished - 2001 Mar 9
Externally publishedYes

Keywords

  • Amyotrophic lateral sclerosis
  • Cu/Zn superoxide dismutase (SOD1) gene
  • Polysialylated neural cell adhesion molecule
  • Transgenic mouse

ASJC Scopus subject areas

  • Neuroscience(all)

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