Induction of podoplanin by transforming growth factor-β in human fibrosarcoma

Hiroyuki Suzuki, Yukinari Kato, Mika Kato Kaneko, Yukari Okita, Hisashi Narimatsu, Mitsuyasu Kato

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Podoplanin/aggrus is increased in tumors and its expression was associated with tumor malignancy. Podoplanin on cancer cells serves as a platelet-aggregating factor, which is associated with the metastatic potential. However, regulators of podoplanin remain to be determined. Transforming growth factor-β (TGF-β) regulates many physiological events, including tumorigenesis. Here, we found that TGF-β induced podoplanin in human fibrosarcoma HT1080 cells and enhanced the platelet-aggregating-ability of HT1080. TGF-β type I receptor inhibitor (SB431542) and short hairpin RNAs for Smad4 inhibited the podoplanin induction by TGF-β. These results suggest that TGF-β is a physiological regulator of podoplanin in tumor cells.

Original languageEnglish
Pages (from-to)341-345
Number of pages5
JournalFEBS Letters
Volume582
Issue number2
DOIs
Publication statusPublished - 2008 Jan 23
Externally publishedYes

Keywords

  • Fibrosarcoma
  • Platelet aggregation
  • Podoplanin
  • Smad
  • TGF-β

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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