Abstract
c-fos and zif268 expression were assessed by immunocytochemistry for c- Fos and Zif268 proteins in the sensory trigeminal nuclear complex following noxious mechanical stimulation of the mandibular incisor pulp of rats. Marked up-regulation of both immediate early genes was observed in the subnucleus oralis ipsilateral to the stimulation. Cavity preparation of the dentine without reaching the pulp did not cause significant up-regulation detectable by immunocytochemistry. These results provide evidence that noxious dental signals reach the ipsilateral subnucleus oralis and up-regulate the transcription of immediate early genes c-fos and zif268.
| Original language | English |
|---|---|
| Pages (from-to) | 353-358 |
| Number of pages | 6 |
| Journal | Brain research |
| Volume | 794 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1998 Jun 1 |
| Externally published | Yes |
Keywords
- C-fos
- Spinal trigeminal tract nucleus
- Subnucleus oralis
- Tooth pulp
- Zif268
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology