Induction of immediate-early genes c-fos and zif268 in the subnucleus oralis by noxious tooth pulp stimulation

Tomosada Sugimoto; Yi Fen He; Makoto Funahashi; Hiroyuki Ichikawa

doi:10.1016/S0006-8993(98)00333-3

Induction of immediate-early genes c-fos and zif268 in the subnucleus oralis by noxious tooth pulp stimulation

Tomosada Sugimoto, Yi Fen He, Makoto Funahashi, Hiroyuki Ichikawa

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

c-fos and zif268 expression were assessed by immunocytochemistry for c- Fos and Zif268 proteins in the sensory trigeminal nuclear complex following noxious mechanical stimulation of the mandibular incisor pulp of rats. Marked up-regulation of both immediate early genes was observed in the subnucleus oralis ipsilateral to the stimulation. Cavity preparation of the dentine without reaching the pulp did not cause significant up-regulation detectable by immunocytochemistry. These results provide evidence that noxious dental signals reach the ipsilateral subnucleus oralis and up-regulate the transcription of immediate early genes c-fos and zif268.

Original language	English
Pages (from-to)	353-358
Number of pages	6
Journal	Brain research
Volume	794
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(98)00333-3
Publication status	Published - 1998 Jun 1
Externally published	Yes

Keywords

C-fos
Spinal trigeminal tract nucleus
Subnucleus oralis
Tooth pulp
Zif268

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(98)00333-3

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title = "Induction of immediate-early genes c-fos and zif268 in the subnucleus oralis by noxious tooth pulp stimulation",

abstract = "c-fos and zif268 expression were assessed by immunocytochemistry for c- Fos and Zif268 proteins in the sensory trigeminal nuclear complex following noxious mechanical stimulation of the mandibular incisor pulp of rats. Marked up-regulation of both immediate early genes was observed in the subnucleus oralis ipsilateral to the stimulation. Cavity preparation of the dentine without reaching the pulp did not cause significant up-regulation detectable by immunocytochemistry. These results provide evidence that noxious dental signals reach the ipsilateral subnucleus oralis and up-regulate the transcription of immediate early genes c-fos and zif268.",

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T1 - Induction of immediate-early genes c-fos and zif268 in the subnucleus oralis by noxious tooth pulp stimulation

AU - Sugimoto, Tomosada

AU - He, Yi Fen

AU - Funahashi, Makoto

AU - Ichikawa, Hiroyuki

PY - 1998/6/1

Y1 - 1998/6/1

N2 - c-fos and zif268 expression were assessed by immunocytochemistry for c- Fos and Zif268 proteins in the sensory trigeminal nuclear complex following noxious mechanical stimulation of the mandibular incisor pulp of rats. Marked up-regulation of both immediate early genes was observed in the subnucleus oralis ipsilateral to the stimulation. Cavity preparation of the dentine without reaching the pulp did not cause significant up-regulation detectable by immunocytochemistry. These results provide evidence that noxious dental signals reach the ipsilateral subnucleus oralis and up-regulate the transcription of immediate early genes c-fos and zif268.

AB - c-fos and zif268 expression were assessed by immunocytochemistry for c- Fos and Zif268 proteins in the sensory trigeminal nuclear complex following noxious mechanical stimulation of the mandibular incisor pulp of rats. Marked up-regulation of both immediate early genes was observed in the subnucleus oralis ipsilateral to the stimulation. Cavity preparation of the dentine without reaching the pulp did not cause significant up-regulation detectable by immunocytochemistry. These results provide evidence that noxious dental signals reach the ipsilateral subnucleus oralis and up-regulate the transcription of immediate early genes c-fos and zif268.

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KW - Spinal trigeminal tract nucleus

KW - Subnucleus oralis

KW - Tooth pulp

KW - Zif268

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Induction of immediate-early genes c-fos and zif268 in the subnucleus oralis by noxious tooth pulp stimulation

Abstract

Keywords

ASJC Scopus subject areas

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