Induction of hypothalamic serum- and glucocorticoid-induced protein kinase-1 gene expression and its relation to plasma des-acyl ghrelin in energy homeostasis in mice

Katsunori Nonogaki, Kana Ohashi-Nozue, Yoshitomo Oka

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Serum- and glucocorticoid-induced protein kinase (SGK) is a serine/threonine-specific protein kinase that is transcriptionally regulated by serum, glucocorticoids, and mineral corticoids. Here, we report that fasting or obesity with hyperphagia increased hypothalamic SGK-1 gene expression. Hypothalamic SGK-1 mRNA levels were proportional to daily food intake and body weights in C57BL6J mice, KK mice, and KKAy mice matched for age. Plasma des-acyl ghrelin, but not active ghrelin, levels were inversely proportional to daily food intake and body weights among these animals. The increases in hypothalamic SGK-1 gene expression in these animals were not accompanied by increases in plasma corticosterone levels. Under conditions of increased energy usage such as fasting, hypothalamic SGK-1 gene expression and plasma des-acyl ghrelin levels were positively correlated while during conditions of increased energy storage, they were negatively correlated. These results suggest that hypothalamic SGK-1 gene is a novel candidate gene involving in energy homeostasis in mice.

Original languageEnglish
Pages (from-to)696-699
Number of pages4
JournalBiochemical and biophysical research communications
Volume344
Issue number2
DOIs
Publication statusPublished - 2006 Jun 2

Keywords

  • Ay mice
  • Corticosterone
  • Energy homeostasis
  • Fasting
  • Ghrelin
  • Hyperphagia
  • Hypothalamus
  • NPY
  • Obesity
  • POMC
  • SGK-1

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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