Induction of HSP90α heat shock mRNA after transient global ischemia in gerbil hippocampus

Jun ichi Kawagoe, Koji Abe, Masashi Aoki, Kyuya Kogure

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Distribution of heat shock protein (HSP) 90α mRNA induction after 10 min of transient global ischemia was investigated in gerbil hippocampus by in situ hybridization. A small amount of HSP90α mRNA was normally present in hippocampal cells and the mRNA was further induced with a peak at 8 h after ischemia. In hippocampal CA1 cells that are vulnerable to ischemia, HSP90α mRNA was continuously induced by 1 day and finally diminished at 2 days. The temporal profile of HSP90α mRNA induction in hippocampal CA1 cells was similar to that of HSP70 mRNA reported previously, suggesting a cooperative role of HSP90α with other HSPs after ischemia.

Original languageEnglish
Pages (from-to)121-125
Number of pages5
JournalBrain research
Volume621
Issue number1
DOIs
Publication statusPublished - 1993 Sep 3

Keywords

  • Cerebral ischemia
  • Gerbil
  • Heat shock protein 90
  • In situ hybridization

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Induction of HSP90α heat shock mRNA after transient global ischemia in gerbil hippocampus'. Together they form a unique fingerprint.

Cite this