Induction of HO-1 gene by viral infection in airways: An inhibitory effect of HO-1 on viral replication

S. Okinaga, M. Yamaya, R. Lee, Y. Numazaki, K. Sekizawa, H. Sasaki

Research output: Contribution to journalArticlepeer-review


Since it became clear that heme oxygenase-1 (HO-1) is a powerful anti- oxidant, many important reports on this topic have been published HO-1 is transcriptionally induced under various stresses as an acute phase protein. Such cytokines as IL-1β, IL-6, and TNF-α, which can induce the HO-1 gene, are produced in the epithelial cells of airways. They exacerbate asthma and other chronic respiratory diseases by causing inflammation in airways. Analysis of the group of cis-elements 5'-upstream of the HO-1 gene suggests that HO-1 is induced by a viral infection which also exacerbates asthma. Indeed, transcription of the HO-1 gene is upregulated in clutured cells after infection by human rhinovirus type 14. Moreover, both cells treated with heroin to accumulate HO-1 protein and cells in which the HO-1 gene was introduced to express HO-1 protein stably were less susceptible to viral infection than were untreated cells. These results suggest that HO-1 has an anti-viral effect.

Original languageEnglish
Pages (from-to)60-65
Number of pages6
JournalJapanese Journal of Thoracic Diseases
Issue numberSUPPL.
Publication statusPublished - 1997


  • Bronchial asthma
  • Gene transcription
  • Heme oxygenase
  • Nitric oxide
  • Rhinovirus

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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