Induction of Fos Immunoreactivity in Oxytocin Neurons in the Paraventricular Nucleus after Female Odor Exposure in Male Rats: Effects of Sexual Experience

Shota Nishitani, Takahiro Moriya, Yasuhiko Kondo, Yasuo Sakuma, Kazuyuki Shinohara

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

1. We examined whether oxytocin (OT) neurons in the paraventricular nucleus of the hypothalamus (PVN) were activated by estrus female odor and sexual contact in sexually naïve and experienced Long-Evans rats. 2. Male rats were not presented to anesthetized estrus females (control) or presented to the females without (exposure to the female odor without sexual contact) or with direct contact (exposure to the female odor with sexual contact). 3. Exposure to the female odor with sexual contact significantly increased OT neurons with Fos-ir in both males. Exposure to the female odor without contact increased OT neurons with Fos-immunoreactive cells (Fos-ir) in sexually experienced males but not in naïve males, suggesting that the female odor without sexual contact activated the oxytocinergic neuronal system in the PVN in the experienced males. 4. Therefore, exposure to the estrus female odor itself may exert different effects on sexually naïve and experienced males.

Original languageEnglish
Pages (from-to)283-291
Number of pages9
JournalCellular and molecular neurobiology
Volume24
Issue number2
DOIs
Publication statusPublished - 2004 Apr 1

Keywords

  • Fos
  • Male
  • Oxytocin
  • PVN
  • Pheromone
  • Sexual behavior

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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