Induction of chromatin damage and distribution of isochromatid breaks in human fibroblast cells exposed to heavy ions.

Tetsuya Kawata, Hisao Ito, Ken Motoori, Takuya Ueda, Naoyuki Shigematsu, Yoshiya Furusawa, Marco Durante, Kerry George, Honglu Wu, Francis A. Cucinotta

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The frequency of chromatid breaks and the distribution of isochromatid breaks were measured in G2-phase normal human fibroblasts prematurely condensed a short time after exposure to low- or high-LET radiations. The average number of isochromatid breaks from a single particle traversal increased with increasing LET values, while the average number of chromatid-type breaks appeared to reach a plateau. The distribution of isochromatid breaks after high-LET iron particles exposure was overdispersed compared to gamma-rays, indicating that a single iron particle traversal through a cell nucleus can produce multiple isochromatid breaks.

Original languageEnglish
Pages (from-to)S169-173
JournalJournal of radiation research
Volume43 Suppl
Publication statusPublished - 2002 Dec
Externally publishedYes

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Health, Toxicology and Mutagenesis

Fingerprint Dive into the research topics of 'Induction of chromatin damage and distribution of isochromatid breaks in human fibroblast cells exposed to heavy ions.'. Together they form a unique fingerprint.

  • Cite this

    Kawata, T., Ito, H., Motoori, K., Ueda, T., Shigematsu, N., Furusawa, Y., Durante, M., George, K., Wu, H., & Cucinotta, F. A. (2002). Induction of chromatin damage and distribution of isochromatid breaks in human fibroblast cells exposed to heavy ions. Journal of radiation research, 43 Suppl, S169-173.