Induction of brain-derived neurotrophic factor (BDNF) and the receptor trk B mRNA following middle cerebral artery occlusion in rat

Shouichi Arai, Hiroyuki Kinouchi, Atsuya Akabane, Yuji Owada, Hideyuki Kamii, Makoto Kawase, Takashi Yoshimoto

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)

Abstract

Middle cerebral artery (MCA) occlusion in halothane-anesthetized rats induced brain-derived neurotrophic factor (BDNF) and the receptor, trk 13 mRNA, in brain. In situ hybridization studies showed that BDNF and trk B mRNAs were induced in a widespread region of the ipsilateral cortex outside the infarct at 4 h following MCA occlusion. They were also induced in the bilateral hippocampi which are remote from the ischemic MCA region. These data show that changes in neurotrophic factor and receptor gene expressions can occur in the areas outside the infarct which could survive.

Original languageEnglish
Pages (from-to)57-60
Number of pages4
JournalNeuroscience Letters
Volume211
Issue number1
DOIs
Publication statusPublished - 1996 Jun 14

Keywords

  • Brain-derived neurotrophic factor
  • Focal cerebral ischemia
  • Hippocampus
  • Spreading depression
  • Tyrosine kinase receptor

ASJC Scopus subject areas

  • Neuroscience(all)

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