Induction of autoimmune gastritis by neonatal thymectomy requires autoantibodies and is prevented by anti-FcγR antibodies

Tsubasa Saito, Satoru Suenaga, Masato Fujii, Yoshihiro Kushida, Yusuke Kawauchi, Kenji Suzuki, Maki Touma, Masamichi Hosono

Research output: Contribution to journalArticle

Abstract

The autoantibodies (auto-Abs) that are a hallmark of neonatally thymectomized (NTx) mice with autoimmune gastritis (AIG) have been poorly explored. We investigated their immune significance using B cell-deficient (B-) mice and found that B- mice are totally resistant to AIG but become susceptible to AIG after receiving bone marrow cells from B+ mice. This susceptibility is most likely caused by the production of auto-Abs by B cells because B- pups also became susceptible to AIG when nourished by an AIG dam producing auto-Abs of the IgG class during the suckling period. NTx B- mice receiving purified IgG auto-Abs at this developmental stage similarly developed AIG. Auto-Abs probably act on antigen handling for antigen presentation because the treatment of NTx B+ mice with anti-FcγR Abs prevented the development of AIG. Auto-Abs are indispensable for AIG development but are not sufficient because auto-Ab treatment did not increase AIG incidence in NTx B+ mice above the baseline.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalCellular Immunology
Volume300
DOIs
Publication statusPublished - 2016 Feb 1
Externally publishedYes

Keywords

  • Anti-FcγR antibodies
  • Autoantibodies
  • Autoimmune gastritis
  • B cell-deficient mice
  • Neonatal thymectomy

ASJC Scopus subject areas

  • Immunology

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