Induction of apoptosis in MCF-7 cells by β-1,3-xylooligosaccharides prepared from Caulerpa lentillifera

Reiko Maeda, Tomoaki Ida, Hideshi Ihara, Tatsuji Sakamoto

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

β-1,3-Xylan was prepared from the green alga, Caulerpa lentillifera, and hydrolyzed to oligosaccharides by a mild acid treatment. The average degree of polymerization was about 5. The oligosaccharides reduced the number of viable human breast cancer MCF-7 cells in a dose-dependent manner, and induced chromatin condensation and degradation of poly ADP-ribose polymerase, indicating that they induced apoptosis in MCF-7 cells.

Original languageEnglish
Pages (from-to)1032-1034
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume76
Issue number5
DOIs
Publication statusPublished - 2012

Keywords

  • Apoptosis
  • Caulerpa lentillifera
  • MCF-7 human breast cancer cell
  • β-1,3-xylooligosaccharide

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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